The effect of Epstein–Barr virus Latent Membrane Protein-1 status on outcome of patients with classic Hodgkin`s Lymphoma. | [Pakistan Journal of Medical Sciences • 2008]

Author(s):

1. Mohammad Ali Rajabi: Department of General Surgery, Isfahan University of Medical Sciences, Isfahan, Iran

2. Parvin Rajabi: Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran

3. Amin Eftekhari: Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran

4. Mehdi Eftekhari: Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran

5. Hamid Reza Ghasemibasir: Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran

6. Ali-Reza Mesbah: Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran

Abstract:

Objective: This study determines the expression of latent membrane protein-1(LMP-1) in lymph nodes of patients with classic Hodgkin lymphoma (cHL) and its role in patients` survival. Methodology: Specimen of 98 patients who had cHL was chosen and the samples were immunohistochemically stained with LMP-1 and Overall disease-free survival (DFS) was measured from the date of complete remission until the Relapse was confirmed by another lymph node biopsy. We investigated the expression of LMP-1in outcome of patients with cHL. Results: LMP-1 was detected in RS cells of cHL in twenty five out of ninety eight (25.5%) patients. LMP-1 expression was significantly more frequent in mixed cellularity, 46.7%, than nodular sclerosis, 15.4% (P= 0.005). Patients with EBV-positive tumors had fewer DFS (22.6 vs. 25.9 mo), but the difference was not statistically significant (p=0.06). Conclusion: Although in our study there is no relationship between age and LMP-1expression. LMP-1 expression is associated with statistically different DFS in treated patients with cHL.

Page(s): 531-536

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 24, Issue: 3, Year: 2008

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