Abstract:
The nutritional approaches are becoming a core element in the prevention of chronic diseases. In this perspective, white button mushroom (Agaricus bisporus) with a variety of untapped potent phytoceutics exhibit promising healthenhancing potential. The research work was designed to evaluate the therapeutic potential of white button mushroom against breast cancer. The breast cancer was induced in rats by the administration of a single dose of 50 mg/kg DMBA via gavage. The rats were divided into four groups: G1 (negative control group), G2 (positive control group), G3 (rats receiving mushroom extract) and G4 (rats administered with doxorubicin). The physical parameters were assessed daily and biochemical parameters were evaluated at three intervals during the study. The Cancer Embryonic Antigen (CEA) level increased maximum (84%) in G2 followed by G3 (71%) and G4 (68.8%). The maximum increase (75%) in CA 15.3 level was measured in G2 followed by G3 (45%) and G4 (27.3%). Similarly, the increase in CRP level (68.3%) in G3 was less than increase in C-reactive protein (CRP) in G2 (93.43%). The measurements of serum antioxidants level revealed that plasma Superoxide dismutase (SOD) concentration decreased maximum (54.83%) in G4 as compared to reduction of SOD level (10.83%) in G2. The SOD level in mammary and liver tissues reduced (31.99% and 35.20%) the most in G2 as compared to G3 (13.85% and 8.79%). The mushroom extract in G3 also effectively controlled catalase and glutathione level. Liver function enzymes were also raised in G2 and G4 as compared to G3. Besides, the Red Blood Cells (RBCs) and hemoglobin (Hb) also reduced maximum in G4 while, in G3 the mushroom extract effectively controlled the level of RBCs and Hb. Conclusively, the mushroom extract contains a variety of phytochemicals possessing therapeutic potential against DMBA-induced breast cancer. Based on the health promoting potential of mushrooms, it is recommended that mushroom should be included as a part of daily diet.
Page(s):
112-112
DOI:
DOI not available
Published:
Journal: International Food & Nutrition Conference" August 18th-20th, 2022, University of Swat, Swat (Book of Abstracts), Volume: 1, Issue: 1, Year: 2022
Keywords:
Breast cancer
,
Button Mushroom
,
Agaricus bisporus
,
Therapeutic potential
References:
References are not available for this document.
Citations
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