The cirrhosis is one of last phases of chronic liver disease. During the development of liver cirrhosis from compensated phase to the decompensated phase, a lot of complications happen that cause remarkable decrease in the life prognosis. The underline diseases like hepatitis B and C, alcohol consumption and non-alcoholic fatty liver disease cause cirrhosis and cirrhosis can easily lead to hepatocellular carcinoma that is type of primary liver cancer and also to liver failure. Thyroid hormones profiling has been linked to worse outcomes for people with cirrhosis. It can be used as effective technique in clinical practices. The main objective of this study was toward the study of the clinical implication of thyroid function in liver cirrhosis in District Gujrat, Punjab, Pakistan. Thyroid hormones (TSH, T3 AND T4) was measured in blood samples taken from participants of experimental and control group over a four-month period as part of a cross-sectional study. Examining the thyroid hormone levels, the severity, and the diagnostic techniques of liver cirrhosis were the main goals. The results showed that there was positive relation between TSH level and child Pugh score. There is also positive relation between TSH level and severity of liver cirrhosis. The results contribute in understanding association of liver disorders and endocrine dysfunction, early diagnosis and management of liver cirrhosis.