Abstract:
Gelatin is a hydrophilic biopolymer which is biodegradable, biocompatible, non-antigenic, harmless, and lots of renewable resources. Therefore, gelatin nanoparticles (GNPs) are proved an efficient carriers for transferring large molecular drugs. Due its hydrophilic characteristic, it dissolves rapidly before reaching the targeted site. Consequently, it is important to maintain the integrity of GNs by crosslinking technique. Since, chemical crosslinking reports unwanted biological effects with gelatin due its protein nature, therefore, it is preferred to employphoto-oxidized crosslinking (POC) method to obtain stable and effective GNPs which produce maximal therapeutic effect. For this purpose PolyEthylene Glycol Dimethacrylate (PEGDMA) is used as photo-oxidized crosslinker which willcrosslinked with gelatin at methacrylol groups under a free radical photoinitiator, like, Omnirad2959 and Poloxamer-407 function as a stabilizer. This resulted formulation is allowed to photocrosslinked under Ultra-Violet (UV) radiation, 100-400nm. Obtained nanoparticles are evaluated physic chemically by different tests. Such as, scanning electron microscopy for morphological studies. Zeta sizer is used for determining the zeta potential of particles and dynamic light scattering give information about particle size. Turbidity of nanosuspension is tested for the confirmation of photocrosslinking by observing the absorbance at 600nm.
Page(s):
19-19
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
Physicochemical
,
PEGDMA
,
photocrosslinking
,
Omnirad2959
,
Gelatin nanoparticles