An autoimmune quandary: discoid lupus erythematosus and HIV coexistence in an Indian patient | [Journal of Pakistan Association of Dermatologists • 2016]

Author(s):

1. S.K Malhotra: Department of Dermatology, Venereology and Leprosy, Government Medical College, Amritsar, India

2. M.L Gambhir: Department of Dermatology, Venereology and Leprosy, Government Medical College, Amritsar, India

3. Jaspreet Kaur Janda: Department of Pathology, Government Medical College, Amritsar, India

4. Anisha Sethi: Department of Dermatology, Venereology and Leprosy, Government Medical College, Amritsar, India

Abstract:

The development of autoimmune diseases in the backdrop of an immune dysfunction in patients with human immunodeficiency virus (HIV) infection is intriguing. An infectious trigger for immune activation is one of the postulated mechanisms and derives from molecular mimicry. Progression from HIV infection to AIDS is associated with a gradual loss of immune-competence. Immune dysregulation and persistent, prolonged immune activation leads to autoimmune phenomena such as lupus and serological abnormalities. We report this sui generis case of discoid lupus erythematosus in HIV positive Indian male for its sheer clinical charm. We also discuss on the probable etiopathogenesis which has not been confounded together so far.

Page(s): 253-256

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 26, Issue: 3, Year: 2016

Keywords:

discoid lupus erythematosus , Human immunodeficiency virus

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