The effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients. | [Journal of Pakistan Medical Association • 2016]

Author(s):

1. Yasar Sertbas: Department of Internal Medicine, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey

2. Meltem Sertbas: Department of Internal Medicine, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey

3. Ugur Ersoy: Department of Internal Medicine, Elazig Medical Park Hospital, Elazig, Turkey

4. Bulent Bilir: Department of Internal Medicine, Namik Kemal University Medical Faculty, Tekirdag, Turkey

5. Seracettin Gunaydin: Department of Biochemistry, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey

6. Ali Ozdemir: Department of Internal Medicine, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey

Abstract:

Objective: To investigate the effect of ezetimibe on platelet functions as a drug which increases mevalonate levels. Methods: This retrospective study was conducted in Istanbul, Turkey, and comprised record of normolipidaemic and hyperlipidaemic patientstaken from the outpatient clinic from October 2004 to February 2015,. The results were taken from the baseline and third-month data of ezetimibe treatment. SPSS 22 was used for statistical analysis. Results: Of the total, there were 50(53%) normolipidaemic patients and 45(47%) hyperlipidaemic ones. Pre- and post-treatment values of mean platelet volume were significantly higher in the hyperlipidaemic group than controls (p0.05). Conclusion: The use of ezetimibe alone should not be the first choice in hyperlipidaemia treatment.

Page(s): 1559-1561

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 66, Issue: 12, Year: 2016

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