New derivatives of tetrahydroharmine, their antibacterial activity and effect on central nervous system. | [Proceedings of Pakistan Academy of Sciences • 1990]

Author(s):

1. Salimuzzaman Siddiqui: HEJ Research Institute Chemistry, University of Karachi, Karachi, Pakistan

2. Bina Shaheen Siddiqui: HEJ Research Institute Chemistry, University of Karachi, Karachi, Pakistan

3. Sabira Begum: HEJ Research Institute Chemistry, University of Karachi, Karachi, Pakistan

4. Akhtar Naeed: HEJ Research Institute Chemistry, University of Karachi, Karachi, Pakistan

5. Khurshid Ali Khan:

Abstract:

In the course of pharmacochemical studies in the harmine series of bases, a number of new derivatives of tetrahydroharmine have been obtained and characterized through spectral studies. Antibacterial tests show that I, II, V-VIII and XII have significant activity against a number of Gram positive and Gram negative bacteria. Studies on their effect on central nervous system show that 11-VII, XII, XVI-HCI and XVII-HCI are CNS stimulants, whereas IX-XI and XV exhibit some signs of depression.

Page(s): 139-152

DOI: DOI not available

Published: Journal: Proceedings of Pakistan Academy of Sciences, Volume: 27, Issue: 2, Year: 1990

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