Cellular Stress Response Induced by Low Dose Gamma Radiation | Proceedings of Pakistan Academy of Sciences 2014

Author(s)

Inayat ur Rahman Gandhara College of Pharmacy, Gandhara University, Peshawar, KPK, Pakistan

Naeem Ullah Jan Gandhara College of Pharmacy, Gandhara University, Peshawar, KPK, Pakistan

Hamid Rasul Niazi Wazir Mohammad Institute of Paramedical Technology, Gandhara University, Peshawar, KPK, Pakistan

Haroon Rahim Department of Pharmacy, Sarhad University of Science and Technology, KPK, Pakistan

Abstract

Low dose radiation-induced damages to DNA are mainly repaired by poly (ADP-ribose) polymerase (PARP-1 and PARP-2) system present in the cell. Suppression of neoplastic transformation of human hybridcells by low doses of low linear energy transfer (LET) radiation is abrogated by PARP enzyme inhibitors andthis presents a new tool in radiotherapy for cancers. The aim of this study was to investigate DNA damages by low doses of gamma rays (2.4 mGy/h) in the presence of inhibitors, 3-aminobenzamide (3-AB) and ANI with the later showing greater increase. These results show DNA repair process reduced and the tail moment increased.

Publication Details

Page(s) 139-144

DOI DOI not available

Published Journal: Proceedings of Pakistan Academy of Sciences, Volume: 51, Issue: 2, Year: 2014

Keywords

Gamma Radiation 100 mGy PARP 24 mGy

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