THE ROLE OF PAROXETINE IN POST- MENOPAUSAL HOT-FLASHES FREQUENCY REDUCTION | [Pakistan Journal of Medicine and Dentistry • 2019]

Author(s):

1. Zareen Naz: Department of Pharmacology, Liaquat College of Medicine and Dentistry,Karachi, Pakistan

2. Moosa Khan: Department of Pharmacology. Shaheed Zulfiqar Ali Bhutto Medical University Islamabad, Pakistan

3. Faiz Ahmed Siddiqui: Department of Radiology. Agha Khan Hospital, Karachi, Pakistan

4. Faiza Siddiqui: Department of Pediatric Medicine, Agha Khan University,Karachi, Pakistan

Abstract:

Background: To evaluate the effects and safety profile of Paroxetine on hot - flashes in post - menopausal women. Methods: It was prospective open label control clinical trial. This study is conducted in the Department of pharmacology & Therapeutics in collaboration with the Department of Obstetrics & Gynecology JPMC. The patients were selected from outpatients department (OPD) of Obstetrics & Gynecology. Duration of the study was 12 month from January 2014 to January 2015. Enrolling 180 outpatients who had menopause with hot flushes divided into three groups. The Greene Climacteric Score Scaling was applied to observe the effects of 12.5mg, 20mg Paroxetine on frequency of hot flashes as compared to Placebo. Results: Mean GCS scoring frequency in 12.5mg Paroxetine group at 12 week was 1.97±0.31 and the baseline 2.64±0.29. In 20mg Paroxetine mean GCS at baseline was 2.76±0.23 and 12 week 2.04±0.12. Where as in Placebo mean GCS scoring frequency at 12 week was 2.80±0.24 and at baseline 2.76±0.24. Conclusion: The frequency of hot flashes with Paroxetine 20mg and 12.5mg, is significantly reduced in post menopauseal women as compared to Placebo.

Page(s): 22-26

DOI: DOI not available

Published: Journal: Pakistan Journal of Medicine and Dentistry, Volume: 8, Issue: 1, Year: 2019

Keywords:

Menopause , Hot flashes , Paroxetine , Greene Climacteric Scale

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