Age-related homocysteine serum levels elevate in men with epilepsy | [Annals of Abbasi Shaheed Hospital & Karachi Medical & Dental College • 2022]

Author(s):

1. Zahir Hussain: Department of Physiology, Faculty of Medicine, Umm Al-Qura University, Pakistan

2. Shabbir Ahmed: Department of Physiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical College, Pakistan

3. Abdulhalim S. Serafi: Department of Physiology, Faculty of Medicine, Umm Al-Qura University, Pakistan

4. Samir Mohammed Abdulfattah Attia: Clinical Pathology, Medical Laboratory Department, University Medical Centre (UMC), Umm Al-Qura University, Pakistan

5. Sumera Sohail: Department of Physiology, University of Karachi, Pakistan

6. Nuvair Zia: Department of Anesthesia, Civil Hospital Karachi, Pakistan

Abstract:

Objectives: The purpose of the present study was to determine the correlation of age with serum homocysteine (Hcy) levels in male non-obese epilepsy (Ep) patients and non-obese male control (C) subjects. Methodology: This case-control study was conducted in non-obese male epilepsy patients (Ep; n: 44; age: 26-40 years) having predominant grand mal (generalized tonic-clonic) seizures and in non-obese male control subjects (C; n: 42; age: 26-40 years). The Ep and C subjects were further subdivided into age-based subgroups: 26-30, 31-35, 36-40 years. Serum Hcy was determined by enzyme-linked immunosorbent assay (ELISA). SPSS software version 24 was used for the purpose of data entry/ statistical analysis. Results: The mean± SD values for serum Hcy (µmol/L) in non-obese male Ep (n:44) and non-obese control male C subjects (n:42) were 12.34±3.34 and 9.16±3.38 respectively that showed a highly significant increase in the level of Hcy (p< 0.001) in Ep compared to C subjects. Serum Hcy levels showed significantly increased serum levels of Hcy and positive linear correlation in all age groups (26-30, 31-35, 36-40, 26-40) in Ep subjects compared to control subjects. However, significantly elevated serum Hcy and lesser association (though significant) of Hcy with age in the Ep group as compared to C subjects were found in the present report. Conclusion: The present study provides evidence of the significant impact of age on serum homocysteine levels in non-obese male epilepsy patients compared to non-obese male control subjects. However, it is essentially required to carry out well-controlled studies comprising wider age range data and a large number of samples in each age subgroup to have a better idea about the potential impact of Hcy in epilepsy and to investigate the comparative effects of antiepileptic drugs (AEDs) and dosages of AEDs on serum levels of Hcy and vice versa.

Page(s): 53-57

DOI: DOI not available

Published: Journal: Annals of Abbasi Shaheed Hospital & Karachi Medical & Dental College, Volume: 27, Issue: 1, Year: 2022

Keywords:

Seizures , Age , Epilepsy , Serum Homocysteine , Nonobese Men , Antiepileptic Drugs

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