Toluidine blue: Yet another low cost method for screening oral cavity tumour margins in Third World countries. | [Journal of Pakistan Medical Association • 2013]

Author(s):

1. Montasir Junaid: Jinnah Medical College Hospital, Karachi, Pakistan

2. Anwar Suhail: Aga Khan University Hospital, Karachi, Pakistan

3. Beena Umer: Aga Khan University Hospital, Karachi, Pakistan

4. Ahmad Nawaz: Dar-ul-Sehat Hospital, Karachi, Pakistan

5. Mubasher Ikram: Aga Khan University Hospital, Karachi, Pakistan

6. Zain-Ul-Abedeen Sobani: Aga Khan University Hospital, Karachi, Pakistan

7. Naeem Sultan Ali: Aga Khan University Hospital, Karachi, Pakistan

Abstract:

Objective: To use toluidine blue intra-operatively to identify tumour involved margins after the removal of oral cavity squamous cell carcinoma, and to compare the findings with those of final histopathology. Methods: The study was conducted at the Aga Khan University Hospital from December 1, 2009, to March 14, 2010, and comprised 56 consecutive patients with biopsy-proven squamous cell carcinoma of oral cavity regardless of grade and stage of tumour. Intra-operatively toluidine blue was used on the resected tumour margins and the staining patterns were assessed. Results were then compared with the final histopathology report. Results: A total of 11(19.64%) margins were positive with toluidine blue staining out of which 8 (14.28%) were false positive. Sensitivity and specificity was found to be 100% and 84.9% respectively with a positive predictive value of 27.2%; a negative predictive value of 100%; and diagnostic accuracy of 85.71%. Conclusion: Toluidine blue costs only Rs25 (USD 0.30) and takes only 5 minutes for application and interpretation. It can be used with significant confidence in smaller lesions (T-I and T-II) as an alternative to frozen sections in developing countries where facilities are unavailable. Its use in larger lesions (T-III and TIV) remains the topic of controversy and awaits a multi centre trial with a larger cohort.

Page(s): 835-837

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 63, Issue: 7, Year: 2013

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views