Thiazolidine Esters: New potent urease Inhibitors. | [Journal of Chemical Society of Pakistan • 2014]

Author(s):

1. Muhammad Arif Lodhi: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan;Department of Biochemistry, UCS Shankar, Abdul Wali Khan University, Mardan, KPK, Pakistan

2. Sulaiman Shams: Department of Biochemistry, UCS Shankar, Abdul Wali Khan University, Mardan, KPK, Pakistan

3. Khalid Mohammad Khan: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

Abstract:

A variety of esters of thiazolidine-4-caboxylic acid were synthesized and investigated for their urease inhibitory properties. A significant increase in urease inhibitory activities of these ester derivatives has been observed. The order of activity increases from methyl ester to heptyl ester but further prolongation of the alkyl chain was proved to be detrimental for receptor binding. These findings provide evidence that the nature of the alkyl chain has a significant impact on the coordination of thiazolidine esters with bi-metallic nickel center of urease. It was also observed that inhibition potentiated by lower pH and with increase in time.

Page(s): 858-864

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 36, Issue: 5, Year: 2014

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views