Synthesis, crystal structure and biological evaluation of 5-arylidine derivatives of 3-phenyl-2-(Phenylimino)thiazolidin-4-one. | [Journal of Chemical Society of Pakistan • 2017]

Author(s):

1. Muhammad Haroon: Department of Chemistry, Mirpur University of Science and Technology (MUST), Mirpur Azad Jammu Kashmir,Pakistan

2. Tashfeen Akhtar: Department of Chemistry, Mirpur University of Science and Technology (MUST), Mirpur Azad Jammu Kashmir, Pakistan.

3. Muhammad Nawaz Tahir: Department of Physics, University of Sargodha, Punjab, Pakistan.

4. Imran Ali: Department of Biotechnology, Mirpur University of Science and Technology (MUST),Mirpur Azad Jammu Kashmir, Pakistan.

5. Shahid Hameed: Department of Chemistry, Quaid-i-Azam University Islamabad, Pakistan.

Abstract:

Arylidene derivatives of 3-phenyl-2-(phenylimino)thiazolidin-4-ones are prepared by its condensation with respective aromatic aldehydes. The structures of synthesized compounds are established using FTIR, 13C-NMR, 1H-NMR, mass spectrometry. The structure of 5-(furan-2ylmethylene)-3-phenyl-2-(phenylimino)thiazolidin-4-one (2c) is also confirmed by X-rays crystallography. The compounds were examined for their antibacterial and enzyme inhibitory effects. Some of the compounds have shown promising activities.

Page(s): 614-618

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 39, Issue: 4, Year: 2017

Keywords:

Thiourea , Thiazolidinones , Xray crystallography , arylidene

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