Variation in quality of the different prepared formulation granules of rhubarb was evaluated by quantitative analysis of multicomponents with single marker | [Pakistan Journal of Pharmaceutical Sciences • 2022]

Author(s):

1. Xiao-liang Fan: Department of Pharmacy, Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing, Zhejiang Province,PR China

2. Chun Zhang: Laboratory of Chinese herbal medicines, Jiaxing Institute for Food, Drug and Product Quality Control,Jiaxing, Zhejiang Province,PR China

3. Yan-bo Shi: Central Laboratory of Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing, Zhejiang Province,PR China

4. Lei-bing Xue: Laboratory of Chinese herbal medicines, Jiaxing Institute for Food, Drug and Product Quality Control,Jiaxing, Zhejiang Province,PR China

5. Jing-jing Wei: Medical College of Jiaxing University,Jiaxing, Zhejiang Province,PR China

Abstract:

Rhei Radix et Rhizoma formula granule (RRFG) , Winy Rhei Radix et Rhizoma formula granule(WRFG) and Rhubarb charcoal formula granules (RCFG) are the three most popular and effective formula granules of rhubarb in China and anthraquinone components are their main active ingredients. In order to discuss the difference in anthraquinone components of these three drugs, a simultaneous quantitative analysis method of multicomponents by single-marker (QAMS) was developed. Emodin was chosed as the internal reference standard, the relative correction factors (RCFs) of aloe-emodin, rhein, chrysophanol and physcion were established and the contents of the four components were calculated based on the RCFs, respectively. Meanwhile, the contents of these components was determined by external standard method (ESM) and compared with QAMS to verify its rationality, feasibility and repeatability. The results showed that there were no significant difference between QAMS and ESM (RSDs=2.26%). The contents of anthraquinone components showed a wide variation in these three drugs. All of 5 components were higher in RRFG than that in the others and RCFG had the lowest content. This method was successfully applied for the evaluation on difference of these drugs and the wide variation in anthraquinone components indicated there were different pharmacodynamic basis.

Page(s): 1095-1101

DOI: 10.36721/PJPS.2022.35.4.REG.1095-1101.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 35, Issue: 4, Year: 2022

Keywords:

QAMS , rhubarb , anthraquinone components , formulation granules

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