The gingival crevicular fluid leptin concentrations in pregnant women with periodontitis: a pilot study. | [Journal of Pakistan Dental Association • 2008]

Author(s):

1. Balwant Rai: Government Dental College, Pt. Bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, Rohtak, Haryana, India

2. S. C. Anand: Government Dental College, Pt. Bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, Rohtak, Haryana, India

3. Simmi Kharb: Government Dental College, Pt. Bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, Rohtak, Haryana, India

Abstract:

Objective: Leptin, a pleiotropic cytokine, regulates various metabolic and endocrine responses, has emerged as an important regulator of inflammation. Also, hyperleptinemia has been reported as a component of metabolic syndrome. Association between periodontitis, pregnancy and cardiovascular risk has been suggested. Hence, the present study was planned to study gingival crevicular fluid (GCF) leptin concentrations in pregnant women with and without periodontitis. Materials and Methods: Twenty five pregnant women with periodontitis and 10 pregnant women as a control were recruited. Leptin (GCF) leptin concentrations were analyzed by competitive ELISA kit. Results: The leptin levels were significantly lower in pregnancy periodontitis patients as compared to normal pregnant women (p

Page(s): 42-44

DOI: DOI not available

Published: Journal: Journal of Pakistan Dental Association, Volume: 17, Issue: 1, Year: 2008

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