The Immunohistocehmical expression of beta human chorionic gonadotrophin (β-HCG) in different grades of human papillary urothelial neoplasm | [Annals of King Edward Medical University • 2023]

Author(s):

1. Ammara Anwar: Social Security Hospital Faisalabad, Pakistan

2. Aamir Imtiaz Khan: Department of Urology, FMU/ Allied Hospital, Faisalabad, Pakistan

3. Asmaa Qureshy: Department of Histopathology, Fatima Jinnah Medical University, Lahore, Pakistan

4. Muhammad Tahir Bashir Malik: Department of Urology, FMU/ Allied Hospital, Faisalabad, Pakistan

5. Asima Naz: Department of Histopathology, Fatima Jinnah Medical University, Lahore, Pakistan

6. Khawaja Moeen-ud-Din: Allama Iqbal Medical College,Lahore Pakistan

Abstract:

Background: Urothelial carcinomais the most common urological malignancy and following prostate and lung cancer, it is the third most common carcinoma in male population Objective: The main aim of this study was to determine the expression of beta hCG in different grades of human urothelial carcinoma in our population. Methods: The study was conducted in Pathology Department of Faisalabad Medical University, Faisalabad, between 2018-2020.Sections were taken on frosted slides for H& E, and on lysine coated slides for IHC.H& E and IHC were performed according to protocols. Results: Out of the 65 tumor studied, 35(54%) were graded as low and 30(46%) were graded as high. In 35 low grade tumors 4(11%) were muscle invasive and 31(89%) were non-invasive and in 30 high grade tumors, 24(80%) were found to be muscle invasive and only 6(20) were non muscle invasive. Out of 65 specimens, 52 (80%) cases were found to be positive for beta hCG while only 13(20% ) were found to be negative of 35 low grade tumors, 27(77%) tumors were stained positive for beta hCG and 8(23%) were negative. Of 30 high grade tumors 25(83%) tumors were stained positive for beta hCG and 5 (17%) were negative. Chi-square test was applied showed that there was no significant association between tumor grade and beta hCG expression. Conclusion: The immunohistochemical expression of beta hCG is positive in majority of low and high grade urothelial carcinoma but it may not be utilized as a marker for prognostic determination.

Page(s): 367-372

DOI: 10.21649/akemu.v23i4.5213

Published: Journal: Annals of King Edward Medical University, Volume: 29, Issue: 4, Year: 2023

Keywords:

Urothelial carcinoma , Beta HCG , muscle invasion

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