The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and its Surrounding Areas | [Pakistan Journal of Analytical & Environmental Chemistry • 2019]

Author(s):

1. Aisha Munawar: Department of Chemistry, University of Engineering and Technology,Lahore, Punjab,Pakistan

2. Zahid Ali: Department of Chemistry, The University of Lahore,Lahore,Pakistan; Department of Chemistry, University of Engineering and Technology,Lahore, Punjab,Pakistan

3. Farzana Muneib: Radio Immuno Assay lab, INMOL Hospital, Lahore, Punjab, Pakistan

4. Abu Baker Shahid: Radio Immuno Assay lab, INMOL Hospital, Lahore, Punjab, Pakistan

5. Ahmed Akrem: Botany Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan, Pakistan H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS),University of Karachi, Karachi, Pakistan.

6. Syed Abid Ali: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS),University of Karachi, Karachi, Pakistan

Abstract:

Inorganic metal ions and the proteins play an essential role in living systems. Different hormonesand cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zincare abundantly distributed in human bodies and play vital role in many biochemical processes.Albumin and ferritin are also the most abundant proteins present in our bodies and carrying out important physiological processes. A disease state or a medical condition can perturb the normal levels of metal ions and proteins in living systems. In the present study, we have analyzed the serum concentration of Ca, Mg, Fe, Zn, albumin and ferritin of hyperthyroid patients. This study includes 184 collected samples (52 normal subjects and 132 hyperthyroid patients), with age group ranging between 11 to 75 years. During sample collection, only those patients were included for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. The hyperthyroid state was determined by the correlation of FT3, FT4 and TSH. Serum Fe, Ca and albumin levels were determined by spectrophotometric method, while Zu and Mg by atomic absorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained results demonstrated the significant differences in the studied parameters as compared to the normal subjects

Page(s): 152-160

DOI: DOI not available

Published: Journal: Pakistan Journal of Analytical & Environmental Chemistry, Volume: 20, Issue: 2, Year: 2019

Keywords:

Iron , Zinc , albumin , Magnesium , Hyperthyroidism , Calcium , TSH , Ferritin

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