Activity of Indoleamine 2, 3 Dioxygenase (IDO) in Type 2 Diabetes Mellitus Patients in Pakistan. | [Journal of Rawalpindi Medical College • 2017]

Author(s):

1. Syed Harris Hussain: Department of Biomedical Engineering, UMM, Heidelberg University, Germany

2. Syed Muarraf Hussain: Department of Physiology, Sahiwal Medical College, Sahiwal, Pakistan

3. Nadeem Ikram: Department of Pathology, Rawalpindi Medical University, Rawalpindi, Pakistan

4. Yasmin Badshah: National University of Sciences and Technology (NUST), Islamabad Pakistan

5. Kashif Asghar: Shaukat Khanum Memorial Cancer Hospital & Research Centre (SKMCH&RC), Lahore, Pakistan

Abstract:

Background: To assess the activity of Indoleamine 2, 3 Dioxygenase (IDO) in Type 2 Diabetes Mellitus Patients in Pakistan Methods: In this prospective study, activity and expression of IDO , was assessed in sera of diabetics and healthy controls (n=28). Colorimetric Assay was performed to analyze IDO activity in samples. Results: A significant difference was observed between the means of control and diabetic patients with a p-value of 0.0001. Conclusion: IDO concentrations were significantly higher in the serum of samples of diabetes mellitus patients as compared to control .

Page(s): 136-140

DOI: DOI not available

Published: Journal: Journal of Rawalpindi Medical College, Volume: 21, Issue: 2, Year: 2017

Keywords:

Indoleamine 2 , dioxygenase , kynurenine pathway

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