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Activity of Indoleamine 2, 3 Dioxygenase (IDO) in Type 2 Diabetes Mellitus Patients in Pakistan.
Author(s):
1. Syed Harris Hussain: Department of Biomedical Engineering, UMM, Heidelberg University, Germany
2. Syed Muarraf Hussain: Department of Physiology, Sahiwal Medical College, Sahiwal, Pakistan
3. Nadeem Ikram: Department of Pathology, Rawalpindi Medical University, Rawalpindi, Pakistan
4. Yasmin Badshah: National University of Sciences and Technology (NUST), Islamabad Pakistan
5. Kashif Asghar: Shaukat Khanum Memorial Cancer Hospital & Research Centre (SKMCH&RC), Lahore, Pakistan
Abstract:
Background: To assess the activity of Indoleamine 2, 3 Dioxygenase (IDO) in Type 2 Diabetes Mellitus Patients in Pakistan Methods: In this prospective study, activity and expression of IDO , was assessed in sera of diabetics and healthy controls (n=28). Colorimetric Assay was performed to analyze IDO activity in samples. Results: A significant difference was observed between the means of control and diabetic patients with a p-value of 0.0001. Conclusion: IDO concentrations were significantly higher in the serum of samples of diabetes mellitus patients as compared to control .
Page(s): 136-140
DOI: DOI not available
Published: Journal: Journal of Rawalpindi Medical College, Volume: 21, Issue: 2, Year: 2017
Keywords:
Indoleamine 2 , dioxygenase , kynurenine pathway
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