3-[(2-chloroquinolin-3-yl)methyl]quinazolin-4(3H)-ones as potential larvicidal agents. | [Pakistan Journal of Pharmaceutical Sciences • 2013]

Author(s):

1. Selvaraj Mohana Roopan: Organic & Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, India

2. Fazlur-Rahman Nawaz Khan: Organic & Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, India; Korea Basic Science Institute, Busan center, Busan, South Korea

3. Jong Sung Jin: Korea Basic Science Institute, Busan center, Busan, South Korea

Abstract:

The larvicidal effect of series of 3-[(2-chloroquinolin-3-yl)methyl]quinazolin-4(3H)-ones, 5a-e, against Chironomus tentans Fabricius has been investigated. The results showed that tested compounds demonstrated strong larvicidal activity, and caused high percentage of mortality after 24 h at the doses of 40-100 μg/ml, especially in the case of 3-[(2-chloro-8-methyquinolin-3-yl)methyl]quinazolin-4(3H)-one, 5b, that act as a promising larvicidal agent.

Page(s): 747-750

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 26, Issue: 4, Year: 2013

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