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The Role of the Microbiome in the Pathogenesis, Phenotype, and Treatment of Asthma
Author(s):
1. Safia Gul: Sardar Bahadur Khan Womens' University,Quetta,Pakistan
2. ismail Mazhar: CMH Lahore Medical College and Institute of Dentistry,Lahore,Pakistan
3. Maryam Maqsood: Sardar Bahadur Khan Womens' University,Quetta,Pakistan
Abstract:
This review article examines the relationship between microbial communities and asthma, emphasizing the microbiome's significant role in asthma development and therapy. Recent developments in the study of the microbiome have shed light on the intricate role that microbial populations play in the etiology and management of asthma. This paper examines the existing evidence regarding the involvement of microbiome dysbiosis in both the exacerbation and onset of asthma, focusing notably on its impact on inflammation and immune system regulation. The disruption of microbial balance in the gut and respiratory tract has been associated with abnormal immune responses, contributing to airway inflammation and heightened reactivity characteristic of asthma. Additionally, microbial metabolites play a substantial role in shaping airway physiology and immune regulation. Innovations in therapy, such as probiotics, prebiotics, and microbial-based treatments, aim to target the microbiome, potentially enhancing asthma management. In summary, understanding the microbiome's role in the pathophysiology and management of asthma represents a major achievement in respiratory medicine by providing new information and prospects for customized therapy for this long-term respiratory illness.
Page(s): 154-162
Published: Journal: Liaquat National Journal of Primary Care, Volume: 7, Issue: 2, Year: 2025
Keywords:
Asthma , Probiotics , Prebiotics , Probiotics , microbiome , Dysbiosis
References:
[1] Azmeh R,Greydanus DE,Agana MG,Dickson CA,Patel DR,Ischander MM .2019 .Update in pediatric asthma: selected issues. Disease-a-Month, 66(4) : 100886.
[2] Pavord ID,Barnes PJ,Lemière C,Gibson PG .2022 .Diagnosis and assessment of the asthma. J Allergy Clin Immunol Pract, 09(1) : 1-8.
[3] Mandlik DS,Mandlik SK .2020 .New perspectives in bronchial asthma: pathological, immunological alterations, biological targets, and pharmacotherapy. Immunopharmacol Immunotoxicol, 42(6) : 521-44.
[4] Ricciardolo FL,Guida G,Bertolini F,Di Stefano A,Carriero V .2023 .Phenotype overlap in the natural history of asthma. Eur Respir Rev, 32(168) : 0201-2022.
[5] Diaconu ID,Gheorman V,Grigorie GA,Gheonea C,Tenea-Cojan TS,Mahler B .2024 .A Comprehensive Look at the Development of Asthma in Children. Children, 11(5) : 581.
[6] Gill R,Kumar R,Singh AP,Singh AP .2024 .Diagnosis and management of asthma: A review. Int J Rural Dev Environ Health Res, 8(2) : 2-35.
[7] Vliex LM,Penders J,Nauta A,Zoetendal EG,Blaak EE .2024 .The individual response to antibiotics and diet-insights into gut microbial resilience and host metabolism. Nature Rev Endocrinol, 14 : 1-2.
[8] Annesi-Maesano I,Cecchi L,Biagioni B,Chung KF,Clot B,Collaud Coen M .2023 .Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?. Allergy, 78(8) : 2121-47.
[9] Pham DL,Le KM,Truong DD,Le HT,Trinh TH .2023 .Environmental allergen reduction in asthma management: an overview. Front Allergy, 4 : 1229238.
[10] Di Simone SK,Rudlof I,Nold-Petry CA,Forster SC,Nold MF .2023 .: eabq5126. Sci Translat Med, 15(678) : .
[11] Chevereau-Choquet M,Thoreau B,Taillé C,Marchand-Adam S,Morel H,Plantier L .2024 .Smoking, urban housing, and workaggravated asthma are associated with asthma severity in a crosssectional observational study. J Asthma Allergy, : 69-79.
[12] Cheng ZX,Wu YX,Jie ZJ,Li XJ,Zhang J .2023 .Genetic evidence on the causality between gut microbiota and various asthma phenotypes: A two-sample Mendelian randomization study. Front Cell Infect Microbiol, 13 : 1270067.
[13] Hufnagl K,Pali-Schöll I,Roth-Walter F,Jensen-Jarolim E . .Dysbiosis of the gut and lung microbiome has a role in asthma. , 42(1) : 75-93.
[14] Aghapour M,Ubags ND,Bruder D,Hiemstra PS,Sidhaye V,Rezaee F . .Role of air pollutants in airway epithelial barrier. , : .
[15] Baloh CH,Mathias RA .2022 .Recent progress in the genetic and epigenetic underpinnings of atopy. J Allergy Clin Immunol, 10(1) : 60-9.
[16] Mormile M,Mormile I,Fuschillo S,Rossi FW,Lamagna L,Ambrosino P .2023 .Eosinophilic airway diseases: From pathophysiological mechanisms to clinical practice. Int J Mol Sci, 24(8) : 7254.
[17] Papadopoulos NG,Apostolidou E,Miligkos M,Xepapadaki P .2024 .3): e14098. Pediatr Allergy Immunol, 35 : .
[18] Rajagopal TV,Kant S,Verma SK,Kushwaha RA,Kumar S,Garg R .2020 .Aspergillus sensitization in bronchial asthma: A separate phenotype. Allergy Asthma Proc, 41(1) : e26-e32.
[19] Van Tilburg Bernardes E,Gutierrez MW,Arrieta MC .2020 .The fungal microbiome and asthma. Front Cell Infect Microbiol, 10 : 583418.
[20] Georas SN,Khurana S. .2024 .Update on asthma biology. J Allergy Clin Immunol, 01 : 1215-28.
[21] Gao J,Yi X,Wang Z. .2023 .The application of multi-omics in the respiratory microbiome: Progresses, challenges and promises. Computat Struct Biotechnol J, 10 : 4933-43.
[22] Yuksel N,Gelmez B,Yildiz-Pekoz A .2023 .Lung microbiota: Its relationship to respiratory system diseases and approaches for lung-targeted probiotic bacteria delivery. Mol Pharma, 20(7) : 3320-37.
[23] Campbell CD,Gleeson M,Sulaiman I. .2023 .The role of the respiratory microbiome in asthma. Front Allergy, 4 : 1120999.
[24] Belizário J,Garay-Malpartida M,Faintuch J .2023 .Lung microbiome and origins of the respiratory diseases. Curr Res Immunol, 4 : 100065.
[25] Song XL,Liang J,Lin SZ,Xie YW,Ke CH,Ao D .2024 .5): e12356. Clin Translat Allergy, 14 : .
[26] Liu XF,Shao JH,Liao YT,Wang LN,Jia Y,Dong PJ . .Regulation of short-chain fatty acids in the immune system. , : .
[27] Kong C,Faas MM,de Vos P,Akkerman R .2020 .Impact of dietary fibers in infant formulas on gut microbiota and the intestinal immune barrier. Food Function, 11(11) : 9445-67.
[28] Spencer J,Bemark M. .2023 .Human intestinal B cells in inflammatory diseases. Nature Rev Gastroenterol Hepatol, 20(4) : 254-65.
[29] Maciel-Fiuza MF,Muller GC,Campos DM,do Socorro Silva Costa P,Peruzzo J,Bonamigo RR .2023 .Role of gut microbiota in infectious and inflammatory diseases. Front Microbiol, 14 : 1098386.
[30] Zhao X,Hu M,Zhou H,Yang Y,Shen S,You Y,Z. Y .2023 .The role of gut microbiome in the complex relationship between respiratory tract infection and asthma. Front Microbiol, 14 : 1219942.
[31] Clemente-Suárez VJ,Beltrán-Velasco AI,Redondo-Flórez L,Martín-Rodríguez A,Tornero-Aguilera JF A .2023 .Global impacts of western diet and its efects on metabolism and health: A narrative review. Nutrients, 15(12) : 2749.
[32] Pedraza Matute S,Iyavoo S. Exploring .2023 .the gut microbiota: Lifestyle choices, disease associations, and personal genomics. Front Nutr, 10 : 1225120.
[33] Bhandary R,Venugopalan G,Ramesh A,Tartaglia GM,Songhay I,Khijmatgar S. .2024 .Microbial symphony: navigating the intricacies of the human oral microbiome and its impact on health. Microorganisms, 12(3) : 571.
[34] Rachman A. .2024 .The impact of lifestyle factors on the human microbiome. Med Stud Health J, 1(1) : 113-22.
[35] Gacesa R,Kurilshikov A,Vich Vila A,Sinha T,Klaassen MA,Bolte LA .2022 .Environmental factors shaping the gut microbiome in a Dutch population. Nature, 604(7907) : 732-9.
[36] Sender S.,R. S. .2016 .Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol, 14 : .
[37] Logoń K,Świrkosz G,Nowak M,Wrześniewska M,Szczygieł A,Gomułka K. .2023 .The Role of the Microbiome in the Pathogenesis and Treatment of Asthma. Biomedicines, 11(6) : 1618.
[38] Martínez JE,Vargas A,Pérez-Sánchez T,Encío IJ,Cabello-Olmo M,Barajas M. .2021 .Human microbiota network: unveiling potential crosstalk between the diferent microbiota ecosystems and their role in health and disease. Nutrients, 13(9) : 2905.
[39] Ney LM,Wipplinger M,Grossmann M,Engert N,Wegner VD,Mosig AS .2023 .Short-chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections. Open Biol, 13(3) : 230014.
[40] Manos J. .2022 .The human microbiome in disease and pathology. Apmis, 130(12) : 690-705.
[41] Ling X,Jie W,Qin X,Zhang S,Shi K,Li T .2022 .Gut microbiome sheds light on the development and treatment of abdominal aortic aneurysm. Front Cardiovasc Med, 9 : 1063683.
[42] Okolie MC,Edo GI,Ainyanbhor IE,Jikah AN,Akpoghelie PO,Yousif E .2024 .Gut microbiota and immunity in health and diseases: A review. Proc Indian Natl Sci Acad, : 1-8.
[43] Fiyouzi T,Pelaez-Prestel HF,Reyes-Manzanas R,Lafuente EM,Reche PA .2023 .Enhancing regulatory T cells to treat inflammatory and autoimmune diseases. Int J Mol Sci, 24(9) : 7797.
[44] Kim YC,Sohn KH,Kang HR .2023 .Gut microbiota dysbiosis and its impact on asthma and other lung diseases: potential therapeutic approaches. Korean J Intern Med, 39(5) : 746-58.
[45] Valverde-Molina J,García-Marcos L J .2023 .Microbiome and asthma: microbial dysbiosis and the origins, phenotypes, persistence, and severity of asthma. Nutrients, 15(3) : 486.
[46] Shin Y,Han S,Kwon J,Ju S,Choi TG,Kang I .2023 .Roles of shortchain fatty acids in inflammatory bowel disease. Nutrients, 15(20) : 4466.
[47] Garg AP,Ateeq A,Bisht N,Patil B .2024 .Management of asthma using probiotics. Explor Asthma Allergy, 2(1) : 9-32.
[48] .2023 .The role of diet and nutrition in allergic diseases. Nutrients, 15(17) : 3683.
[49] Hammad H,Lambrecht BN .2021 .The basic immunology of asthma. Cell, 02(6) : 1469-85.
[50] Berdnikovs S,Newcomb DC,Hartert TV .2024 .How early life respiratory viral infections impact airway epithelial development and may lead to asthma. Front Pediatr, 12 : 1441293.
[51] Vitte J,Vibhushan S,Bratti M,Montero-Hernandez JE,Blank U .2022 .Allergy, anaphylaxis, and no allergic hypersensitivity: IgE, mast cells, and beyond. Med Princ Pract, 31(6) : 501-15.
[52] De Vleeschhauwer F,Casteels K,Hofman I,Proesmans M,Rochtus A .2024 .Systemic adverse events associated with locally administered corticosteroids. Children, 11(8) : 951.
[53] Nightingale K,Lin KM,Ravenhill BJ,Davies C,Nobre L,Fielding CA .2018 .High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host Microbe, 07(3) : 447-60.
[54] Wu TD,Diamant Z,Hanania NA .2024 .An update on patient-reported outcomes in asthma. Chest, 02(5) : 1049-57.
[55] de Oliveira DE,Leitão CG,Falcão FO,de Paiva Torquato JP,Neto JD,de Castro MA .2024 .5): e14513545933. Res Soc Develop, 13 : 45933.
[56] Krings JG,Beasley R .2024 .The role of ICS-containing rescue therapy versus SABA alone in asthma management today. J Allergy Clin Immunol Pract, 01(4) : 870-9.
[57] Ma Y,Zhao H,Su Y. .2024 .Ozone pollution and acute exacerbation of asthma in residents of china: An ecological study. J Asthma Allergy, : 951-60.
[58] Kithara C,Kuniyoshi KM,Rehan VK .2023 .Preterm birth, developmental smoke/nicotine exposure, and life-long pulmonary sequelae. Children, 10(4) : 608.
[59] Shen K,Zhang M,Zhao R,Li Y,Li C,Hou X .2023 .Eosinophil extracellular traps in asthma: Implications for pathogenesis and therapy. Respirat Res, 24(1) : 231.
[60] Jasemi SV,Khazaei H,Morovati MR,Joshi T,Aneva IY,Farzaei MH .2023 .Phytochemicals as a treatment for allergic asthma: Therapeutic efects and mechanisms of action. Phytomedicine, : 155149.
[61] Sardon-Prado O,Diaz-Garcia C,Corcuera-Elosegui P,KortaMurua J,Valverde-Molina J,Sanchez-Solis M .2023 .Severe asthma and biological therapies: now and the future. J Clin Med, 12(18) : 5846.
[62] Armillei MK,Lomakin IB,Del Rosso JQ,Grada A,Bunick CG .2024 .Scientific rationale and clinical basis for clindamycin use in the treatment of dermatologic disease. Antibiotics, 13(3) : 270.
[63] Tashiro H,Takahashi K,Uchida M,Kurihara Y,Sadamatsu H,Takamori A .1861 .Efect of azithromycin on exacerbations in asthma patients with obesity: Protocol for a multi-center, prospective, single-arm intervention study. Int J Environ Res Public Health, 20(3) : .
[64] Parnham MJ,Norris V,Kricker JA,Gudjonsson T,Page CP .2023 .Prospects for macrolide therapy of asthma and COPD. Adv Pharmacol, 03 : 83-110.
[65] Van Dijck C,Laumen JG,de Block T,Abdellati S,De Baetselier I,Tsunamis A .2023 .The oropharynx of men using HIV pre-exposure prophylaxis is enriched with antibiotic resistance genes: A crosssectional observational metagenomic study. J Infect, 02(4) : 329-37.
[66] Garg AP,Ateeq A,Bisht N,Patil B .2024 .Management of asthma using probiotics. Explor Asthma Allergy, 2(1) : 9-32.
[67] Shimokawa C,Kanaya T,Hachisuka M,Ishiwata K,Hisaeda H,Kurashima Y .2017 .Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections. Immunity, 04(5) : 863-74.
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