Fabrication and evaluation of lipid based nano encapsulation of vildagliptin | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Asiya Farheen: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

2. Asia Naz: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

3. Munair Badshah: Islam College of Pharmacy, Pasrur Road, Sialkot, Punjab, Pakistan

4. Majeed Ullah: Department of Pharmacy, Kohat University of Science and Technology, Kohat, KP, Pakistan

Abstract:

Lipid nanoparticles have potential to design sustained release of short half-life drugs to improve pharmacokinetic features. Conventional dosage forms of Vildagliptin (VLG) require frequent doses due to rapid metabolism and it is beneficial to enhance its duration of action for controlled drug delivery. In this research, we fabricate and optimize sustained release vildagliptin loaded nanoparticles via microemulsion and solvent evaporation, solvent diffusion emulsion. Glycerylbehenate used for used for solid lipid nanoparticles. The prepared drug-loaded nanoparticles were characterized using FTIR spectroscopy, HPLC and DSC-TGA) confirmed morphology and thermal stability. Fractional factorial design was employed to understand the effect of formulation factors like surfactant concentration, L/D ratio and drug content on particle size, drug loading and encapsulation efficiency. In-vitro drug release profile of formulated nanoparticles revealed more than 24 h sustained release of drug. It concludes lipid based nanoparticles may have potential to design sustained release drug delivery system using dipeptidyl peptidase-4 (DPP-4) inhibitor agent.

Page(s): 69-69

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

Vildagliptin , sustained release drug , Compritol® 888 ATO , delivery , Solid lipid nanoparticle

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