Anti irritant activity of extract from the aerial parts of Echinops echinntus Compositae. | Pakistan Journal of Scientific and Industrial Research Series B: Biological Sciences 2012

Author(s)

Muhammad Zaheer Applied Chemistry Research Center, PCSIR Laboratories Complex, Shahrah-e-Jalaluddin Roomi, Lahore-54600, Pakistan

Naqi Hussain Applied Chemistry Research Center, PCSIR Laboratories Complex, Shahrah-e-Jalaluddin Roomi, Lahore-54600, Pakistan

Salma Rahman Applied Chemistry Research Center, PCSIR Laboratories Complex, Shahrah-e-Jalaluddin Roomi, Lahore-54600, Pakistan

Sajid-ur-Rehman Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Abstract

Present study was focused on anti irritant potential of a xerophytic weed, Echinops echinatus. For this purpose, petroleum ether, chloroform and methanol extracts of various polarities from the aerial parts of E. echinatus were collected. Five fractions i.e., Ee-1 to Ee-5 were isolated from the chloroform extract of powdered plant by column and thin layer chromatography. The anti irritant potential of these fractions were evaluated on rabbit s skin. The anti irritant activity was evaluated from the healing mechanism on the abraded and irritated animal s skin. Two fractions (Ee-2 and Ee-4) appeared to be the potent anti irritant than others.

Publication Details

Page(s) 40-45

DOI DOI not available

Published Journal: Pakistan Journal of Scientific and Industrial Research Series B: Biological Sciences, Volume: 55, Issue: 1, Year: 2012

Keywords

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