Abstract:
Stress is described as a noxious stimulus that effect the health of an individual and alters body homeostasis resulting in behavioral, physical and biological reactions which changes the individual behavioral and metabolic condition. Prolonged stress causes numerous neurochemical and neurostructural changes in the brain. Treatments for stress condition help to decrease the symptoms but these current therapies are less effective and produce severe side effects. So, the novel drugs are required with more effective and fewer lethal outcomes. Synthesis of drug from plants has main interest due the significant medicinal values. Medicinal plants possess various bioactive components which can be utilized for the synthesis of drugs. Ficuscarica is the member of a family Moraceae. It has various beneficial effects. Effects of Ficuscarica leaves extract on acute and chronic stress was not reported so, the recent investigation was designed to examine the pharmacological impacts of extract of Ficuscarica leaves on stress. Rodents were randomly assigned as (n=6) control and stressed group. Different stressors at random order were given to the stressed group animals while the control animals were undisturbed in their cages. Acute effects were monitored after 7 days of exposure with stressors and chronic impacts of stress were observed after 28 days. The result revealed that acute unpredictable mild stress produced anxiogenic behavior and decreased locomotor and ambulatory activity but depression like symptoms remain unaffected by the acute stress. Spatial working memory was significantly impaired following acute stress. Depression like symptoms and anxiogenic behaviour was produced after exposure with the chronic unpredictable mild stress. Biochemical investigation showed that prolonged stress leads to elevate glucose and cholesterol level and reduced HDL and triglycerides levels in experimental rats. In the second stage of investigation the animals were randomly distributed as (n=6) control, stressed rats and Ficuscarica leaves extract treated stressed rats. Control animals were kept at standard condition while stressed group animals were exposed with different stressors. Third group of Ficuscarica leaves extract treated stressed rodents was exposed to stress and treated with Ficuscarica extract at the dose of 100 mg/kg. Acute behavioral alteration was observed after 7 days and prolonged impact was monitored after the 28 days. The current finding showed that administration of Ficuscarica leaves extract produced anxiolytic behaviors and decreased depression like symptoms in CUMS treated rats. Administration of leaves extract of Ficuscarica also increased stimulatory, ambulatory, locomotor activity and enhanced spatial working memory and recognition memory in CUMS exposed rats. So, it can be concluded from recent study that leaves of Ficuscarica can be utilized as secure drug for curing physiological stress with less side effect profile.
Page(s):
393-393
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023