THYROID HORMONES AND CARDIOVASCULAR HOMEOSTASIS; A REVIEW | [Pakistan Heart Journal • 2018]

Author(s):

1. Sarmad Ahmad Qamar: Department of Biochemistry, Government College University,Faisalabad ,Pakistan

2. Zahed Mahmood: Department of Biochemistry, Government College University,Faisalabad ,Pakistan

3. Naveed Munir: Department of Biochemistry, Government College University,Faisalabad ,Pakistan

4. Muhammad Jahangeer: Department of Biochemistry, Government College University,Faisalabad ,Pakistan

5. Aneela Basharat: Department of Biochemistry, Government College University,Faisalabad, Pakistan

Abstract:

Two iodinated hormones, 3,5,3-triiodothyronine (T3) and 3,5,3,5tetraiodothyronine; also known as thyroxine (T4) are secreted by thyroid gland. Thyroid hormones interact with specific receptors on myocardial and vascular endothelial tissues to induce chemical changes and these tissues are very sensitive for a small fluctuation in circulating thyroid hormones. The obtained data from different experimental and clinical studies revealed significance of normal thyroid hormones to maintain the cardiovascular homeostasis. Even subtle fluctuation in the concentration of thyroid hormone as in subclinical hypothyroidism or hyperthyroidism could significantly affect the cardiovascular system. In this review article we will understand how thyroid hormones interacts with specific receptors on myocytes and induces many genomic as well as nongenomic alterations directly and indirectly including due to dyslipidemia, blood pressure changes and endothelial dysfunction.

Page(s): 264-272

DOI: DOI not available

Published: Journal: Pakistan Heart Journal, Volume: 51, Issue: 4, Year: 2018

Keywords:

hypothyroidism , Hyperthyroidism , Hyperthyroidism , Hormones , Cardiovascular , Homeostasis

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