Herbal medication (Garlina) attenuates cholesterol diet induced hyperlipidemia in wistar rats | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Farzana Sadaf: Department of Pharmacology, Karachi, Pakistan

2. H. Maaz: Department of Pharmacognosy, Karachi, Pakistan

3. Syed Waleed Ahmed Bokhari: Department of Pharmacognosy, Karachi, Pakistan

4. L. Anwar: Department of Pharmacology, Karachi, Pakistan

5. M. Azam: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan.

Abstract:

Herbal medicines have gain popularity among people due to abundant and affordable remedies with high efficacy and least side effects. Most of the herbal drugs are used to cure cardiovascular ailments. This signifies the therapeutic importance of medicinal plants and stresses the necessity of research on these herbal medicines. The present study has been carried out on a product Garlina obtained from Hamdard Laboratories (Waqf) Pakistan for the treatment of cardiovascular diseases especially atherosclerotic plaque in experimental models. Anti- hyperlipidemic activity of Garlina was determined on high cholesterol diet (HCD) induced hyperlipidemic rat model. The findings revealed that the Garlina (200mg/kg) shows the significant reduction in body weight (from 212.8 ± 4.5 to 200.0 ± 4.1) when compared to HCD group (from 201.6 ± 4.2 to 262.4 ± 4.1). Garlina significantly (p< 0.01) reduced food intake (8.0 ± 0.1 g/day by 27.2%, 7.5± 0.04 g/day by 37.4% and 7.0± 0.1g/day by 44.6% respectively as compared to high cholesterol-diet (14.0 ± 0.2 g/day by 40.3%) rats. There is dose dependent decrease in organ and serum lipid biochemistry at the doses of 50, 100 and 200 mg/kg of Garlina as compared to high cholesterol diet rats for a period of 60 days. It is therefore concluded that Garlina exhibited remarkable decrease in lipid profile in cholesterol induced hyperlipidemic rat models and exhibited pronounced inhibition in atherosclerotic lesions.

Page(s): 295-295

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

Lipid profile , High Cholesterol Diet , Herbal medicine , Garlina , Anti hyperlipidemic activity

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