When antithyroid drugs must be started in patients with hyperemesis gravidarum. | [Pakistan Journal of Medical Sciences • 2009]

Author(s):

1. Najafipour Farzad: Department of Endocrinology and Metabolisem, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

2. Aliasgarzadeh Akbarz: Department of Endocrinology and Metabolisem, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

3. Aghamohammadzadeh Naser: Department of Endocrinology and Metabolisem, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

4. Mobasseri Majid: Department of Endocrinology and Metabolisem, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract:

Objective:Tofind out role of anti-thyroid drugs in patients with Hyperemesis gravidarum and thyroid dysfunction. Methodology:One hundred thirty five patients with hyperemesis gravidarum who were admitted to obstetric and gynecology hospital were enrolled in this study. Thirty two patients were excluded because of diabetes mellitus and thyroid diseases. Hence, one hundred three patients underwent investigations including thyroid function test and β-hCG (Human chorionic gonadotropin). Results:Thirty five women were found with abnormal thyroid function test with FT4I (Free Thyroxin Index) 4.74±0.54 and in another group (68 women) was 2.9±0.39 (PConclusion:In our study thyroid dysfunction in hyperemesis gravidarum was 35% and, 20% of patients needed anti-thyroid therapy. Routine assessment of thyroid function is necessary for women with hyperemesis gravidarum especially in patients with clinical features of hyperthyroidism. We must consider PTU (propylthouracil) in hyperemesis gravidarum with severe weight loss, vomiting and biochemical hyperthyroidism.

Page(s): 61-64

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 25, Issue: 1, Year: 2009

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