A comparative neurobehavioral study of sesame oil and fish oil on experimental animals | [Pakistan Journal of Pharmaceutical Sciences • 2020]

Author(s):

1. Sadaf Naeem: Hamdard University,Madinat al-Hikmah, Karachi,Pakistan; Jinnah Sindh Medical University, Institute of Pharmaceutical Sciences,Karachi,Pakistan

2. Liaquat Ali: Hamdard University,Madinat al-Hikmah, Karachi,Pakistan

3. Ghazala H Rizwani: Hamdard University,Madinat al-Hikmah, Karachi,Pakistan

4. Rahila Ikram: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan

5. Saira Saeed Khan: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan

6. Huma Shareef: Jinnah Sindh Medical University, Institute of Pharmaceutical Sciences,Karachi,Pakistan

7. Ishrat Younus: Hamdard University,Madinat al-Hikmah, Karachi,Pakistan

8. Tabinda Zareen Malick: Jinnah Sindh Medical University, Institute of Pharmaceutical Sciences,Karachi,Pakistan

9. Umer Aleem: Saidu Medical College,Swat, Khyber Pakhtunkhwa,Pakistan

Abstract:

Natural oils are enriched with polyunsaturated fatty acids (PUFAs) which are important for our health. Recent experimental data explained that PUFAs might have a beneficial effect on various brain functions such as anxiety, dementia, epileptic seizures, depression or bipolar and other neurobehavioral diseases. The objective of the current research work was to evaluate the effect of sesame oil, fish oil and mixture of both oils (1:1) on neurobehavioral changes and cognition. For this purpose shark fish oil and sesame oil were extracted out and there poly unsaturated and saturated fatty acids were analyzed by using GCFID that exposed the presence of different PUFs in shark fish oil, sesame oil and mixture of both oils. Neurobehavioral changes were seen after 5ml/kg/day sesame oil, 5ml/kg/day shark fish oil and 1:1 combination of both oil 5ml/kg/day administration on open field, cage crossing, light and dark, stationary rod, forced swimming induced depression test and water maze test. Our GCFID results showed sesame and fish oil enriched with higher amount of PUFs and showed significant anxiolytic and antidepressant like effect after 30 days of treatment (P<0.05) however combination of these both oils exhibited greater efficacy (P<0.01) in reducing anxiety and depression as imipramine standard drug. Results showed that combination of both oils (sesame oil and fish oil) could be a better option to treat neurobehavioral problems as compared to alone.

Page(s): 511-521

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 33, Issue: 2, Year: 2020

Keywords:

PUFs , neurobehavioral diseases

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