TIMP-1 and MMP-9 expressions in COPD patients complicated with spontaneous pneumothorax and their correlations with treatment outcomes | [Pakistan Journal of Medical Sciences • 2020]

Author(s):

1. Hang Li: Department of Thoracic and Cardiovascular Surgery,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Jiangsu Province, P. R. China.

2. Kaihu Shi: Department of Thoracic and Cardiovascular Surgery,Nanjing Integrated Traditional Chinese andWestern Medicine Hospital,Jiangsu Province P. R. China / Academy of Traditional Chinese Medicine,100 Shizi Street, Hongshan Road,Nanjing 210028,Jiangsu Province, P. R. China.

3. Yang Zhao: Department of Thoracic and Cardiovascular Surgery,Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Jiangsu Province, P. R. China

4. Jin Du: Department of Thoracic and Cardiovascular Surgery,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Jiangsu Province, P. R. China

5. Dinghui Hu: Department of Thoracic and Cardiovascular Surgery,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Jiangsu Province, P. R. China

6. Zuntao Liu: Department of Thoracic and Cardiovascular Surgery,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Jiangsu Province, P. R. China

Abstract:

Objective: To study the expressions of TIMP-1 and MMP-9 in patients with chronic obstructive pulmonary disease (COPD) complicated with spontaneous pneumothorax, and their correlations with treatment outcomes. Methods: A total of 80 COPD patients complicated with spontaneous pneumothorax treated in our hospital from December 2015 to December 2017. The serum expressions of TIMP-1 and MMP-9 in 80 COPD patients complicated with spontaneous pneumothorax (COPD group) and 52 healthy volunteers (control group) were detected by ELISA. The correlations of TIMP-1 and MMP-9 expressions with arterial blood gas parameters as well as scores of MRC breathlessness scale and St. George's Respiratory Questionnaire (SGRQ) were analyzed. Results: The serum expressions of TIMP-1 and MMP-9 of COPD group were significantly higher than those of control group (P0.05). For COPD group, TIMP-1 expression, MMP-9 expression, MMP-9/TIMP-1, Sa(O2) and p(O2) were not correlated (P>0.05). TIMP-1 expression was significantly positively correlated with MRC scale and SGRQ scores (P<0.05). Sa(O2), p(O2) and MRC scale score of low MMP-9 expression, low TIMP-1 expression and low MMP-9/TIMP-1 group were significantly improved compared with those of high MMP-9 expression, high TIMP-1 expression and high MMP-9/TIMP-1 group (P<0.05). MMP-9 expression, TIMP-1 expression or MMP-9/TIMP-1 was not correlated with improvement of SGRQ score. Pulmonary function improvement (Sa(O2) improvement rate =5% and/or p(O2) improvement rate =10%) was correlated with serum MMP-9 expression, baseline Sa(O 2) and p(O2). Conclusion: Increase of serum TIMP-1 and MMP-9 expressions in COPD patients was correlated with symptoms and scores of quality of life, and the expressions were also correlated with short-term treatment reactivity.

Page(s): 192-197

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 36, Issue: 2, Year: 2020

Keywords:

Tissue inhibitor of metalloproteinase1

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