To Compare the effect of Nepafenac versus Prednisolone on Post-Operative Inflammation and Intraocular Pressure after Cataract Surgery | [Journal of Islamic International Medical College • 2020]

Author(s):

1. Asim Mehboob: Department of Ophthalmology, Combined Military Hospital, Kharian, Pakistan

2. Muhammad Usman Arshad: Department of Ophthalmology, Islamic International Medical College, Riphah International University, Islamabad, Pakistan

3. Faran Bin Afzal: Department of Ophthalmology, Alshifa Trust Eye Hospital, Rawalpindi, Pakistan

4. Sohail Zia: Department of Ophthalmology, Islamic International Medical College, Riphah International University, Islamabad, Pakistan

5. Aneeq Ullah Baig Mirza: Department of Ophthalmology, Islamic International Medical College, Riphah International University, Islamabad, Pakistan

6. Masud Ul Hassan: Department of Ophthalmology, Bashiran Umer Eye Hospital, Rawalpindi, Pakistan

Abstract:

Objective: To compare the effect of topical 0.1% Nepafenac and 1% prednisolone in control of inflammation and maintenance of Intraocular Pressure (IOP) after cataract surgery. Study Design: Randomized control trial. Place and Duration of Study: Department of Ophthalmology, from 4th June 2018 to 30th June 2019. Materials and Methods: Total sample size of study population was 400, including all patients getting phacoemulsification cataract surgery. Study population was equally divided in two groups. Group 1 was Nepafenac group, and Group 2 was Prednisolone group. Both groups underwent cataract extraction, and were started on topical 0.1% Nepafenac or 1% Prednisolone along with topical antibiotics after surgery. Postoperative IOP and activity and flare was checked in all patients on day 1, 7 and 28 after surgery and compared between both groups. Results: The study population had a mean age of 60.97±4.91 years. The proportion of male and female patients in study population was 51% and 49% respectively. Difference in mean post-operative IOP and mean change from pre-operative value between both groups was statistically significant (p=0.003 and 0.004 respectively). There was statistically significant difference between both groups in terms of anterior chamber cells and flare respectively at 1st week post-operatively (p=0.002, and 0.003). However, there was no statistically significant difference between both groups in terms of anterior chamber cells and flare respectively after 28 days postoperatively (p=0.12, and 0.71). Conclusion: Nepafenac is superior to prednisolone in controlling IOP after cataract surgery, with adequate and comparable control of post-surgical inflammation.

Page(s): 23-27

DOI: DOI not available

Published: Journal: Journal of Islamic International Medical College, Volume: 15, Issue: 1, Year: 2020

Keywords:

Prednisolone , Intraocular Pressure , Nepafenac

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views