A Study of Thrombocytopenia in Neonatal Sepsis | [Pakistan Paediatric Journal • 2019]

Author(s):

1. HUMA SALEEM KHAN: Foundation University Medical College, Fauji Foundation Hospital Rawalpindi, Pakistan

2. SUMAIRA KHALIL: Foundation University Medical College, Fauji Foundation Hospital Rawalpindi, Pakistan

3. KIRAN MUSHTAQ TOOR: Foundation University Medical College, Fauji Foundation Hospital Rawalpindi, Pakistan

4. Munir Akmal Lodhi: Foundation University Medical College, Fauji Foundation Hospital Rawalpindi, Pakistan

5. AwaisTahir: Foundation University Medical College, Fauji Foundation Hospital Rawalpindi, Pakistan

6. Parveen Akhtar: Foundation University Medical College, Fauji Foundation Hospital Rawalpindi, Pakistan

Abstract:

Objective: This study aims to determine the occurrence, severity and association of thrombocytopenia in neonatal sepsis and to analyze its utility as an important screening tool in neonatal sepsis. Study Design: Descriptive study Place and Duration of Study: Study was conducted in Neonatal intensive care unit (NICU) of Fauji Foundation Hospital from 1st June 2016 to 30th May 2018. Material and Methods: We retrospectively collected data of all Rawalpindi newborns admitted in NICU with culture proven sepsis. Association of variables like type of organisms causing sepsis with thrombocytopenia sEu-mmaaiirl:akhalil @hotmail.com and mortality using Pearson chi-square test was assessed. P -value < 0.05 was considered significant. Results: Total newborns with positive blood culture were 70. Thrombocytopenia was observed in 65.7% of neonates. Severe thrombocytopenia was more commonly associated with gram negative organisms (80.4%) as compared to gram positive organisms (37.5%) with p-value of 0.001. Significant mortality was contributed by gram negative organisms (87%). p- value of 0.03. Conclusion: Thrombocytopenia is an early predictor of septicemia. Sepsis caused by gram negative organisms is more commonly associated with thrombocytopenia and with high risk of mortality.

Page(s): 239-243

DOI: DOI not available

Published: Journal: Pakistan Paediatric Journal, Volume: 43, Issue: 4, Year: 2019

Keywords:

Neonatal sepsis , Thrombocytopenia , Culture proven sepsis

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