Targeting oxidative stress in diabetic complications: new insights | [International Journal of Biology and Biotechnology • 2020]

Author(s):

1. Misbah Sultana: Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan

2. Saima Jadoon: Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan

3. Arif Malik: Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan

Abstract:

This review summarizes the fundamental role of reactive oxygen species in diabetes mellitus pathophysiology. In diabetes mellitus, hyperglycemia is the main causative element of oxidative stress. Hyperglycemia is not only responsible to generate ROS but it also attenuates mechanism of antioxidants via scavenging of substances and enzymes. Diabetes complications caused by oxidative stress includes nephropathy, neuropathy and retinopathy. Free radicals developed are neutralized through exogenous and endogenous antioxidants, in order to protect the cells from their harmful toxic effects. Although, antioxidant therapeutic approach is useful, still it's necessary to investigate the efficacy of this cure strategy.

Page(s): 663-667

DOI: DOI not available

Published: Journal: International Journal of Biology and Biotechnology, Volume: 17, Issue: 4, Year: 2020

Keywords:

ROS , hyperglycemia , Oxidative stress , Diabetic

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