Acquired Megaesophagus Associated with Accidental Overdose of Vincristine in a Dog. | [Pakistan Veterinary Journal • 2019]

Author(s):

1. Min-Joo Chae: Cheonan Animal Medical Center,Chungcheongnam-do, 31181,South Korea: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University,Seoul, 05029,South Korea

2. Tae-Woo Kim: Cheonan Animal Medical Center,Chungcheongnam-do, 31181,South Korea

3. Hee-Myung Park: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University,Seoul, 05029,South Korea

4. Min-Hee Kang: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University,Seoul, 05029,South Korea

Abstract:

A 15-year-old, castrated male, mixed dog presented for evaluation of bilateral submandibular lymphadenopathy. Fine needle aspiration of the lymph node revealed multicentric lymphoma, and chemotherapy was performed following CHOP protocol. After first administration of vincristine, anorexia, hemorrhagic diarrhea and regurgitation were noted. An accidental overdose of vincristine was found and symptomatic treatment was initiated to prevent the further adverse reaction of chemotherapy. However, an acquired megaesophagus was noted the next day and there was no clinical improvement. The dog died 17 days after the accidental high-dose vincristine administration. This is first case described an acquired megaesophagus in association with accidental overdose administration of vincristine during chemotherapy in a dog.

Page(s): 320-322

DOI: 10.29261/pakvetj/2018.097

Published: Journal: Pakistan Veterinary Journal, Volume: 39, Issue: 2, Year: 2019

Keywords:

Dog Megaesophagus Overdose Vincristine

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