Abstract:
Objective To evaluate the therapeutic efficacy of terbinafine in comparison with itraconazole in treatment of tinea capitis. It is pertinent to mention that tinea capitis is a pronounced disease of Southern Punjab with specific prevalence in children of Bahawalpur and surroundings in prepubertal stage, which merits a definite consideration owing to inherent implications and limitations of the disease. Methods The Prospective comparative study conducted at health care centers of southern Punjab. It comprised 100 children aged 5-16 years, with clinically and mycologically confirmed tinea capitis by 10-30% KOH microscopy and by Sabouraud agar. The children randomized to 8 weeks' treatment with terbinafine or 8 weeks with itraconazole. Evaluation criteria resorted to constitute inspection of random sample of patient at 0, 2, 4 and 8-week interval. Efficacy analysis based upon pooled data and photographic documentation. Outcome determined by absence of clinical signs. Safety assessment included monitoring of the frequency and severity of adverse events (AEs). Hepatic safety of itraconazole (Azole group) determined by LFTs after 4-week treatment. Data analysis conducted with SPSS and graph pads. Result presented in tabular and pictorial form. Results There were 80 cases in both group A (Terbinafine) and group B (Itraconazole), with no tremendous contrast as far as average age, weight, pre-treatment, total sign and symptom score and number of sores. Fix was seen remarkably superior in bunch B where 70 (87.5%) cases were relieved when contrasted with bunch A where 56 (70%) cases were restored. The tolerability was likewise essentially better in bunch B, where 62 (77.5%) sufferers have either excellent or great reaction to medicate resilience as compare to bunch A where it is noticed in 42 (52.5%) sufferers. Conclusion Itraconazole manifest noteworthy benefits with regards to cure rate, time requires for rehabilitation and acceptability which appears differently in relation to terbinafine.
Page(s):
474-483
DOI:
DOI not available
Published:
Journal: Journal of Pakistan Association of Dermatologists, Volume: 33, Issue: 2, Year: 2023
Keywords:
Itraconazole
,
Terbinafine
,
Abstract
,
eolgtTinea Capitis