Yield of Gene Expert and ZN Staing in diagnosis of Pulmonary and Extra Pulmonary Tuberculosis | [Pakistan Journal of Medical and Health Sciences • 2020]

Author(s):

1. Nabi Rehman: Mardan Medical Complex /Bacha Khan Medical Complex, Swabi, Pakistan

2. Muhammad Haroon Taj: Khyebr Medical University Institute of Medical Sciences (Khyber Institute of Medical Sciences),Kohat, Pakistan

3. Ajmaal Jami: Isra Medical University Karachi, Pakistan

4. Aneela Qureshi: IsraMedical University,Karachi, Pakistan

5. M Zahid Shah: Baqai Medical University Karachi, Pakistan

6. Noor Khaliq Jan: Naseer Ullah Khan Babar Memorial Teaching Hospital Kohat Road Peshawer, Pakistan

Abstract:

Objective: To determine the prevalence of pulmonary and multi drug resistant TB in patients visited outpatients for respiratory problems. Study Design: Descriptive, Cross-Sectional Place and Duration: Conducted at Medicine Department of Mardan Medical complex, Bacha Khan Medical College, Mardan for duration of one year from 15st January 2019 to 14 January, 2020. Methods: Total 4600 patients were included in this study. Patients were divided into two groups. Group A had 1100 patients and treated by Gene Xpert technique and the group B had 3500 patients checked by Zhiel Neelsen (ZN) Staining. Patients detailed demographics were age, sex were recorded after taking written consent. Complete data was analyzed by SPSS 24.0 version. Results: Out of 1100 patients in group A 715 (665%) were males and 385 (35%) patients were females, and MTB was detected in 320 (29.09%) patients. In group B 2400 (68.6%)patients were males and 1100 (31.4%) were females, out of these 430 (12.3%) cases showed smear positive. Frequency of rifampicin was 20 (6.25%) out of 320 patients of MTB. Conclusion: We concluded in this study that gene Xpert is effective for diagnosis of tuberculosis and drug resistant TB while smear positive had many other advantages.

Page(s): 1950-1951

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 4, Year: 2020

Keywords:

Tuberculosis , Multidrug resistant TB , ZN Staining , gene xpert

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