Visual and Topographical Outcomes Following Accelerated Trans-epithelial Corneal Crosslinking in Progressive Keratoconus. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2017]

Author(s):

1. Kanwal Latif: Department of Ophthalmology, Sir Syed College of Medical Sciences and Hospital, Karachi, Pakistan

2. Muhammad Saeed Iqbal: Department of Ophthalmology, Sir Syed College of Medical Sciences and Hospital, Karachi, Pakistan

Abstract:

Objective: To assess the visual and topographical outcomes following accelerated trans-epithelial corneal crosslinking (TE-CXL) in progressive keratoconus. Study Design: Case series. Place and Duration of Study: Laser Vision Centre, Karachi, from January 2015 to December 2016. Methodology: Forty-five eyes of 25 patients affected with progressive keratoconus and treated with accelerated TE-CXL with riboflavin (vitamin B2) and ultra-violet A (UV-A) irradiation were enrolled in this study. The visual outcome was measured by ETDRS chart as improvement in best corrected visual acuity (BCVA) of at least one line or more as compared to pre-CXL BCVA. The topographical outcome was measured as decrease in maximum simulated keratometry values, astigmatism and spherical equivalent (SE) and an increase in central corneal thickness (CCT). K-max was defined as the steepest radius of curvature of the anterior corneal surface. SE was measured by subjective refraction, and K-max, astigmatism and CCT by scanning-slit corneal topography. Patients were followed-up 12 months post-treatment. Results: At the end of follow-ups, mean BCVA showed improvement of one line from LogMAR 0.58 ±0.067 to LogMAR 0.48 ±0.077. Seven (15.5%) eyes showed two lines of improvement while 3 (6.7%) eyes showed worsening of one line in BCVA. The mean K-max flattened by 0.7D. Mean astigmatism and SE decreased up to -0.5D and -0.4D, respectively. Mean preoperative CCT was 454.31 ±36.34 µm, whereas mean postoperative CCT was 456.47 ±35.60 µm with an average increase of 2.15 µm. No postoperative complications were reported. Conclusion: Based on topographical outcomes, accelerated TE-CXL is effective in preventing the progression of keratoconus without any safety concerns with improvement of vision in majority of cases.

Page(s): 552-555

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 27, Issue: 9, Year: 2017

Keywords:

Keywords are not available for this article.

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