Synthesis, spectral investigation (1H, 13C) of new (N, O and S based) schiff bases and evaluation of their antimicrobial activities | [Journal of Chemical Society of Pakistan • 2011]

Author(s):

1. Muhammad Kaleem Khosa: Department of Chemistry, Government College University, Faisalabad, Pakistan

2. Madhia JAMAL NISAR: Department of Chemistry, Government College University, Faisalabad, PAKISTAN

3. Muhammad Asghar: Department of Chemistry, Government College University, Faisalabad, PAKISTAN

4. Muhammad YOUSAF: Department of Chemistry, Government College University, Faisalabad, PAKISTAN

5. Shahzad Ali Shahid CHATHA: Department of Industrial Chemistry, Government College University, Faisalabad, PAKISTAN

6. Khalid Mahmood Zia: Department of Industrial Chemistry, Government College University, Faisalabad, Pakistan

7. Khalil-Ur-Rehman NULL: Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan

Abstract:

Three new series of biologically active amino substituted Schiff bases (1-12) with general formula, R1N=CHR2 (R1 = 2-amino-benzthiazole, 4-amino-salicylic acid and 4-aminophenol; R2 = benzaldehyde, 2-chloro-benzaldehyde, 4-chloro-benzaldehyde, salicylaldehyde and vanillin) were synthesized by the reaction of three different amino substituted compounds and substituted aldehydes in ethanol. The synthesized compounds were characterized by different physico-chemical techniques like, melting point, elemental analysis, multinuclear nmr (1H, 13C). The compounds were subjected for bioassay screening and showed promising antibacterial and antifungal activities using Amoxicillin and Ciprofloxacin as standard drugs.

Page(s): 421-425

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 33, Issue: 3, Year: 2011

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