A novel approach to diagnose and treat coronavirus in dogs (Canis lupus familaris) | International Journal of Agriculture and Biology 2023

Author(s)

Muhammad Umer Sulehria University of Veterinary and Animal Sciences,Lahore, Pakistan

Syed Saleem Ahmad University of Veterinary and Animal Sciences,Lahore, Pakistan

Muhammad Ijaz University of Veterinary and Animal Sciences,Lahore, Pakistan

Muhammad Hassan Mushtaq University of Veterinary and Animal Sciences,Lahore, Pakistan

Asfand Yar Khan University of Veterinary and Animal Sciences,Lahore, Pakistan

Abstract

This study was conducted with an aim to diagnose canine coronavirus (CCoV) and to determine the antiviral effect of an antimalarial drug chloroquine (CQ). A total of thirty (n = 30) PCR-confirmed CCoV positive dogs (Canis lupus familaris) were randomly selected and included in the study for the drug trial. These 30 dogs were further divided into two groups; A (control) & B (treatment) containing 15 dogs each. Blood samples were collected from every dog to study the hematobiochemical parameters, i.e., CBC, LFTs and RFTs during the course of the experiment. In group A, 5 out of 15 dogs recovered and remained alive while 10 died (mortality rate 66.7%). In group B, 10 out 15 dogs recovered and 5 out of 15 died during the course of this study (mortality rate 33.7%). CQ should be considered for treatment in CCoV as it has good antiviral activity against coronavirus in dogs. © 2023 Friends Science Publishers

Publication Details

Page(s) 426-430

DOI 10.17957/IJAB/15.2049

Published Journal: International Journal of Agriculture and Biology, Volume: 29, Issue: 6, Year: 2023

Keywords

PCR Chloroquine Dog Antiviral Clinical trial Canine coronavirus Invitro study

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