Formulation and evaluation of polymeric nanosuspensions of meloxicam with its enhanced analgesic effect in mice | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Rabia Noor: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan

2. Syed Muhammad Farid Hasan: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan

3. Shazia Haider: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan

4. Faheema Siddiqui: Department of Pharmacology, Faculty of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan

5. Ijaz Ahmed: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan

Abstract:

Meloxicam belongs to Biopharmaceutics Classification System (BCS) class II drugs possessing poor water solubility. It has analgesic and anti-inflammatory properties. Poor solubility restricts drug release and hinders in producing desired effect in analgesia. The present study designed to increase the solubility of drug to produce more analgesic effect than pure meloxicam. A total of four polymeric nanosuspensions were made using chitosan and soluplus®by bottom-up method. Among all formulations, one polymeric nanosuspension found more promising in various physicochemical tests. The potent formulation subjected to in-vivo analgesic activity (Hot plate test followed by formalin test) in albino mice (22 to 26kg) with different doses along with pure meloxicam. The results of optimized nanosuspension showed better response at low dose with less IC50 value as compared to pure meloxicam with respect to control. Similarly, in formalin test (consisting of early and late phases)the optimized formulation produced more response in both phases especially in late phase of formalin test than pure meloxicam. Therefore, it can be concluded that chitosan along with soluplus®can be used to increase the solubility of meloxicamin order to produce more analgesic effect than pure compound.

Page(s): 145-145

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

analgesic , Nanosuspension , Bottomup , Poor solubility , meloxicam

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