Active case detection among household contacts of multi drug resistant tuberculosis patients in a tertiary care setting. | [Pakistan Journal of Medical Research • 2014]

Author(s):

1. Sana Rehman: PMRC TB Research Centre, King Edward Medical University, Lahore, Pakistan;Mayo Hospital, Lahore, Pakistan

2. Muhammad Kashif Muni: PMRC TB Research Centre, King Edward Medical University, Lahore, Pakistan;Mayo Hospital, Lahore, Pakistan

3. Rizwan Iqbal: PMRC TB Research Centre, King Edward Medical University, Lahore, Pakistan;Mayo Hospital, Lahore, Pakistan

4. Arslan Ahmed Salam: PMRC TB Research Centre, King Edward Medical University, Lahore, Pakistan;Mayo Hospital, Lahore, Pakistan

5. Saqib Saeed: Institute of Chest Medicine, Mayo Hospital, Lahore, Pakistan

6. Faisal Masud: King Edward Medical University, Lahore, Pakistan;Mayo Hospital, Lahore, Pakistan

7. Muhammad Aasim: PMRC TB Research Centre, King Edward Medical University, Lahore, Pakistan;Mayo Hospital, Lahore, Pakistan

Abstract:

Background: Close contacts of multi drug resistant tuberculosis patients are expected to be at increased risk of developing the disease and therefore need screening on priority basis to have an effective TB control program. Active household contact screening is an effective and cheaper way to detect and treat MDR-TB at its early stages. Objectives: To determine active TB cases among household contacts of MDR-TB patients in a tertiary care setting. Study type, settings and duration: Descriptive study, conducted at PMRC TB Research Centre in collaboration with Institute of Chest Medicine, King Edward Medical University/Mayo Hospital, Lahore from November 2012 to December 2013. Patients and Methods: Patients suffering from MDR-TB and seeking treatment from Institute of Chest Medicine were selected as index patients. Their contacts (spouses, children, parents, siblings and other relatives) underwent sputum smear microscopy. Those found positive for AFB were subjected for MTB RIF assay by GeneXpert to determine rifampicin resistance. Data was analysed using IBM Statistics SPSS version 20.0. Results: A total of 692 contacts of 112 MDR-TB patients were studied. Among them, 374(54 %) were males and 318(46%) female). Seventeen contacts were found smear positive and of these 15(88%) were also confirmed as MTB by GeneXpert. Four (23%) contacts were rifampicin resistant. Of the affected contacts, majority were sisters (23.5%). Conclusion: Active TB was detected in contacts of patients having MDR-TB with few also showing rifampicin resistance. Policy message: TB screening should be done in all contacts of TB patients, especially those having drug resistance.

Page(s): 55-59

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Research, Volume: 53, Issue: 3, Year: 2014

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