Abstract:
The rapid escalation of bacterial resistance and microbial evolution in recent decades demands the urgent need for more effective treatments and novel antiSmicrobials. In this work, heterocyclic Schiff base ligands were synthesized by reacting primary amine derivatives with various aromatic aldehydes and ketones in 1:1 and 1:2 molar ratios. The resulting imine based ligands were characterized using physical parameters (solubility, color, melting point), spectroscopic techniques (UV-Vis, FT-IR, 1H and 13C NMR, MS), and elemental analysis. Density functional theory (DFT) calculations were performed to validate experimental (UV Vis, FT-IR) results and investigate electronic properties (FMO, NBO, MEP, MAC), with global reactivity parameters derived from FMO energy gaps indicating potential bioactivity. The ligands were subsequently employed to synthesize 3d- transition metal complexes in 1:1 and 1:2 molar ratios, which were characterized by physical data (color, solubility, decomposition points) and structural analyses (FT-IR, UV-Vis, MS, magnetic moments, molar conductance). Antibacterial and antifungal assays against selected strains revealed that most synthesized compounds, particularly the metal complexes, exhibited strong antimicrobial activity, in several cases when compared with standard drugs. These findings highlighted the potential of the synthesized ligands and their metal complexes as promising candidates for future biomedical applications.
Page(s):
18-18
DOI:
DOI not available
Published:
Journal: 4th International Conference of Sciences “Revamped Scientific Outlook of 21st Century, 2025” , November 12,2025, Volume: 1, Issue: 1, Year: 2025