The Role of Cytokines in Depression and Sleep Regulation | [Pakistan Journal of Medical and Health Sciences • 2020]

Author(s):

1. FIROOZEH NOURIMAND: Vali Asr Educational Hospital, Fasa University of Medical Sciences,Fasa,Iran

2. SEDIGHE FOROUHARI: Research Center of Quran, Hadith and Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3. SEYED ZIAEDDIN TABEI: Department of Medical Ethics and Philosophy of Health, Shiraz University of Medical Sciences,Shiraz,Iran

4. BAHIA NAMAVAR JAHROMI: Department of Obstetrics & Gynecology, Infertility Research Center, Shiraz University of Medical Sciences,Shiraz,Iran

5. MOHAMMAD NAMI: Department of neuroscience, School of advanced medical sciences and technologies, Shiraz University of Medical Sciences,Shiraz,Iran

6. BEHROOZ GHARESIFARD: Department of Immunology, Faculty of Medicine, Infertility Research Center, Shiraz University of Medical Sciences,Shiraz,Iran

7. ABDOLREZA MAHMOUDI: Islamic Education Department, Faculty of Medicine, Shiraz University of Medical Sciences,Shiraz,Iran

8. TAHEREH POORDAST: Department of Obstetrics & Gynecology, Infertility Research Center, Shiraz University of Medical Sciences,Shiraz,Iran

Abstract:

Background: There is an interrelationship between the biological clock, the nervous system and the immune system in college students. Psychological and behavioral factors impact the immune system and this changes affect the depression and neural status of the individual. Methods: All students who entered the Shiraz University of Medical Sciences from 2016-2017, were potentially eligible to participate in this randomized field trial. The sample size was 152 students divided into 2 groups: Sleep and wakefulness workshop and Control group. Finally, 119 of 156 participants entered in the study, Beck depression inventory and Pittsburgh sleep Quality Index. Result: Based on the results, comparison of depression in the intervention group before and after workshop, had a significant decrease. For PSQ analysis, intra-group comparisons in those who participated in the sleep and awakening workshop showed that the change was significant. Our findings showed that in our participant, depression and sleep quality had a positive and significant relationship with Human IL-1ß, Human IL-8 and Human IFN-?. Conclusion: Based on the findings of the Psycho-Neuro-Endocrine-Immunology, there is a reciprocal relationship between the biological system and sleep (based on the biological clock), the nervous system and the immune system and the changes in the immune system affect the mental and nervous conditions of the individual.

Page(s): 676-680

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 1, Year: 2020

Keywords:

cytokines , Depression , sleep

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