The Relationship Between the Serum High-Mobility Group Protein B1 (HMGB1) Level with the Severity of the Patient's Condition in Different Severe Pneumonia Patients Complicated with Acute Respiratory Distress Syndrome (ARDS). | [RADS Journal of Pharmacy & Pharmaceutical Sciences • 2016]

Author(s):

1. Yanqiu Gao: Respiratory Intensive Care Unit, Zhengzhou Central Hospital Afiliated to Zhengzhou University, Zhengzhou city, PR China

2. Min Liu: Cardiovascular internal medicine, Zhengzhou Central Hospital Afiliated to Zhengzhou University, Zhengzhou city, PR China

3. Hua Zhang: Respiratory Intensive Care Unit, Zhengzhou Central Hospital Afiliated to Zhengzhou University, Zhengzhou city, PR China

Abstract:

Objective To observe the serum high-mobility group protein B1( HMGB1) level in severe pneumonia patients complicated with acute respiratory distress syndrome( ARDS) and explore its relation to the severity of the patient's condition. Methods Thirty-six severe pneumonia patients complicated with ARDS received mechanical ventilation in ICU between 2012 and 2014 were selected, and the patients were divided into survival group( n= 21) and death group (n= 15)according to prognosis. At 1- and 3-day and the day of discharge from ICU or death, serum HMGB1 level was detected by enzyme-linked immunosorbent assay( ELISA) ,and the Acute Physiology and Chronic Health Evaluation II( APACHE II) score was made. Sixteen healthy subjects for physical examination in the same time were selected as control group. Results:At 1- and 3-day and the day of the death, serum HMGB1 level and APACHE II scores presented increase tendency( all P<0.01) in death group and they presented decrease tendency at day 1-,3day and the day of discharge from ICU(all P<0.01) in survival group. The serum HMGB1 levels of three time-points decreased in the order of death group, survival group and control group (all P<0.01). APACHE II scores of three-points in death group were all significantly higher than those in survival group (all P<0.01). Serum HMGB1 levels were positively correlated with the APACHE scores ( r =0. 691,P<0.01) . ConclusionSerum HMGB1 level in severe pneumonia patients complicated with ARDS is positively correlated with the disease severity, and thereby it can serve a clinical index to assist evaluating disease condition and judging prognosis.

Page(s): 123-127

DOI: DOI not available

Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 4, Issue: 1, Year: 2016

Keywords:

Acute respiratory distress syndrome , Severe pneumonia , Acute Physiology and Chronic Health Evaluation II score , Highmobility group protein B1

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