Schiff-Bases and its polymeric nanoparticles as antibacterial agents: synthesis, characterization and therapeutic potential | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Shazia Haider: Dept. of Pharmaceutical Chemistry, University of Karachi, Karachi, Pakistan

2. Madiha Hamid: Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

3. Saima Tauseef: Dept. of Microbiology, Federal Urdu University of Arts, Science & Technology, Karachi, Pakistan

4. Ijaz Ahmed: Dept. of Pharmaceutical Chemistry, University of Karachi, Karachi, Pakistan

Abstract:

Antimicrobial resistance has become a gigantic problem worldwide. The increasing resistance against the marketed drug is the mismanagement use of antibiotics drugs. According to the Centers for Disease Control and Prevention antibiotic resistance report from the year of 2012 to 2017 in the U.S., more than 35, 000 deaths and 2.8 million infections annually have been reported. AMR has become a global challenge. Synthetic Schiff bases and theirpolymeric nanoparticles (PNPs) were characterized by different techniques and were investigated against three bacterial strains, by the disc diffusion method. The compounds which exhibited significant activity were further investigated by minimum inhibitory concentration against the marketed drug Gentamicin. From the results it could be concluded that natural polymers encapsulated the Schiff bases have increased the bioavailability of the drug which has shown moderate to significant inhibitions against these strains. These are responsible for the upper respiratory tract infections caused by S. pneumonia, and urinary tract infections by Proteus spp. Additionally, typhi has become a life-threatening disease due to extreme multidrug resistance which is easily transferred by contaminated food and water.

Page(s): 185-185

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views