Vitamin D levels and bone mineral density in inborn errors of metabolism requiring specialised diets | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2019]

Author(s):

1. Asburce Olgac: Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Turkey

2. Asli Inci: Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Turkey

3. Ilyas Okur: Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Turkey

4. Fatih Ezgu: Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Turkey

5. Gursel Biberoglu: Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Turkey

6. Leyla Tumer: Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Turkey

Abstract:

Objective: To evaluate vitamin D levels and bone mineral density in patients with dietary limitations due to inborn errors of metabolism (IEM) and its correlation with diets. Study Design: Retrospective study. Place and Duration of Study: Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University Hospital, Turkey, from March to Semtember 2016. Methodology: The study is a retrospective review of 115 patients. Information about vitamin D status, bone mineral density (BMD) measurement and anthropometric parametres were collected. Patients were divided into two major groups, receiving protein-restricted diets (n=83) and lactose-restricted diets (n=32). Data of 110 healthy children were used as the control group. Results: Mean vitamin D level of patients with special diets 28.1 ±14.9 ng/ml while mean level of healthy controls was 26.6 ±12.27 ng/ml. Levels of 26.8% (n=26/97) patients were found to be deficient and 34% (n=33/97) were found to be insufficient. No statistically significant differences were found between vitamin D levels and BMD of patients and healthy controls. BMD was not influenced by vitamin D levels. Conclusion: Low BMD may be encountered in IEM, independent of vitamin D levels and revision of diet for adequacy of essential nutrients; and follow-up for dietary compliance is inevitable.

Page(s): 1207-1211

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 29, Issue: 12, Year: 2019

Keywords:

Vitamin D , Diet , inborn errors of metabolism , Bone health , Galactosemia , Glycogen storage disorders

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