Adipocyte triglyceride content and adipogenesis in aripiprazole treated rats. | [International Journal of Pharmacology • 2013]

Author(s):

1. Zsolt Gall: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy of Targu Mures, Targu Mures, Romania

2. Szende Vancea: Department of Physical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Targu Mures, Targu Mures, Romania

3. Tibor Mezei: Department of Pathology, Faculty of Medicine, University of Medicine and Pharmacy of Targu Mures, Targu Mures, Romania

4. Melinda Kolcsar: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy of Targu Mures, Targu Mures, Romania

Abstract:

The atypical antipsychotic treatment is associated with weight gain and alteration of glucose and lipid metabolism. The effects of aripiprazole which is a third generation antipsychotic drug associated with reduced weight gain, were investigated on adipose tissue. The triglyceride content of adipose tissue along with adipocyte`s lipid droplet size was determined. The experiments were performed using adult, female Wistar rats, divided in 3 groups as follows: Control group (n = 8) -vehicle, aripiprazole 4 mg kg-1 b.wt. (n = 8) and aripiprazole 8 mg kg-1 b.wt. (n = 8). The drugs were administered orally twice daily for 32 days. Samples were taken from perirenal area, triglyceride content of cells was determined using colorimetric enzymatic method. Histological evaluation of the perirenal adipose tissue was performed by morphological characterization of adipocytes. The triglyceride content of adipocytes was significantly lower in the aripiprazole treated groups than in control (p0.05). Evaluating the lipid droplet size distribution, we found significant difference between control and treated groups (p

Page(s): 251-257

DOI: DOI not available

Published: Journal: International Journal of Pharmacology, Volume: 9, Issue: 4, Year: 2013

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