Abstract:
More than half of the world's population believes in several plant extracts as a new, safer and costeffective treatment options due to their promising potentials against various illnesses such as cancers and infectious diseases. However, poor bioavailability of most of the plant extracts limits their use as medicinal agents and these challenges can overcome by modern technology such as nanoparticle synthesis of plant extracts. Amongst many nanocarrier systems, Polymer-Lipid Hybrid Nanoparticles have gained attention as they prevent the drawbacks associated with other nano-carrier system especially polymeric and lipid nanoparticles. In the present study, four formulations FPC1, FCA1, FPA3& FCC3 of Polymer Lipid Hybrid Nanoparticles (PLHNPs) of Peanut Skin Extract and Carrot Root Extract were fabricated using Chitosan & Sodium Alginate as polymers, Lecithin as lipid and Tween-80 as surfactant and then optimized dependingupon their physicochemical properties particularly particle size to provide the scientific evidence for their efficacy as anticancer and antimicrobial agents. Two optimized Formulations FPC1& FCC3 which had chitosan as a polymer were found to produce more prominent antimicrobial activities against all test microorganisms (Gram Positive bacteria S. aureus & B. subtilis, Gram Negative bacteria E. coli & P. aeruginosa and fungi Candida albicans & Aspergillus niger) at same concentrations as that of their free drugs and standards Gentamicin and Fluconazole. FPC1 emerged as most potent inhibitor against Candida albicans even greater than standard Fluconazole. However, Polymer-Lipid Hybrid Nanoparticles with Sodium Alginate polymer were found devoid of significant effect. For anticancer potentials, % inhibition on PC3 cell lines by fabricated nanoparticles formulations FPA3& FCC3 showed improved results in comparison to their free drugs (Peanut Skin Extract & Carrot Root Extract) while on HeLa Cell lines, only FPA3 showed better results when compared to its free drug Peanut Skin Extract. However, PLHNPs didn't show remarkable results when compared to standard Doxorubicin. The present study showed the increasing potential of the plant extracts (Peanut skin and carrot root extract) as anticancer and antimicrobial agents through Polymer-Lipid Hybrid Nanoparticles fabrication and highlighted the vital role of Polymer-Lipid Hybrid Nanoparticles in nanotechnology field as a simple, reliable and eco-friendly process for nanoparticles synthesis. Therefore, further investigation in future is recommended for the Polymer-Lipid Hybrid Nanoparticles fabrication of plant extracts with controlled drug delivery, using different polymers and lipids which can provide scientific evidences for potential candidates against several cancers and diseases such as endocarditis, meningitis, Candidiasis and Aspergillosis, respiratory, gastrointestinal and urinary tract, skin and wound infections.
Page(s):
179-179
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
antimicrobial
,
Plant extracts
,
Anticancer
,
Nanotechnology
,
Carrot Root Extract
,
Peanut Skin extract