Abstract:
Several N-acylcyclobutanecarboxamides have been synthesized and examined for general central nervous system depressant properties, barbiturate potentiation, myore laxant, antitremorine and anticonvulsant potency. Water solubility appears to play a major role in the activity of these compounds. N-4-Hydroxybutyrylcyclobutanecar-boxamide, the most potent myorelaxant of the series, appears to be more potent than most of the clinically used strychnine antagonists. N-Methacrylyl, N-phenylacetyl, N-3, 5-dimethoxybenzoyi, N-furoyl and N-3, 4, 5-trimethoxybenzoylcyclobutanecarboxamides are moderate active tremorine antagonists. None of the compounds is active against pentylenetetrazole induced convulsions.
Page(s):
107-109
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Scientific and Industrial Research, Volume: 16, Issue: 3--4, Year: 1973