Thermal degradation of 7,8-dim ethyl- 10-formylmethylisoalloxazine in acid solution: A kinetic study. | [Journal of Chemical Society of Pakistan • 2008]

Author(s):

1. Iqbal Ahmad: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

2. Faiyaz Hussain Madani Vaid: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

Abstract:

The thermal degradation of 7, 8-dimethyl-10-formylmethylisoalloxazine (FMF) in acid solution under anaerobic conditions has been studied A specific spectrophotometric method has been used to determine FMF in the presence of degrada0on products. FMF has been found to undergo second-order reaction in the dark to form lumiehrome and side chain products. The second-order rate constants for the reactions at 40-60 oC are in the range of 1.05 - 4.40 L mole-1 min-1. The activation energy and the frequency factor for the reaction have been calculated as 15.0 kcal/mole (62.8 kj/mole) and 2.43 x 1010 L mole-1 min-1 respectively. A reaction scheme for the bimolecular degradation of FMF has been suggested.

Page(s): 688-691

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 30, Issue: 5, Year: 2008

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