Tectochrysin Attenuates Cisplatin-induced Hepatotoxicity by Restoring Biochemical, Inflammatory and Histological Profile in Rats | [Pakistan Veterinary Journal • 2023]

Author(s):

1. Muhammad Umar Ijaz: Department of Zoology, Wildlife and Fisheries, University of Agriculture,Faisalabad,Pakistan

2. Zainab Rafi: Department of Zoology, Wildlife and Fisheries, University of Agriculture,Faisalabad,Pakistan

3. Ali Hamza: Department of Zoology, Wildlife and Fisheries, University of Agriculture,Faisalabad,Pakistan

4. Muhammad Tariq: Department of Livestock Management, University of Agriculture,Sub-campus Toba Tek Singh,Pakistan

5. Saad Alkahtani: Department of Zoology, College of Science, King Saud University,P.O. Box 2455, Riyadh 11451,Saudi Arabia

6. Abdullah A. Alkahtane: Department of Zoology, College of Science, King Saud University,P.O. Box 2455, Riyadh 11451,Saudi Arabia

7. Mian Nadeem Riaz: Texas A & M University, College Station,TX 2476,USA

Abstract:

Cisplatin is an efficacious anticancerous chemotherapeutic agent that is used to cure multiple types of malignancies. However, it has several hazardous effects on multiple organs, particularly liver. Tectochrysin is a naturally occurring flavonoid with extensive pharmacological properties. In this research, the potential antioxidant properties of tectochrysin against cisplatin-triggered oxidative stress in rats' hepatic tissues were investigated. 48 male albino rats were separated into 4 groups: control cisplatin (10 mg/kg), cisplatin + tectochrysin (10 mg/kg + 5 mg/kg), and tectochrysin (5 mg/kg). The trial executed for one month. The biochemical, inflammatory, histopathological and liver markers were evaluated. The results of the research suggested that cisplatin treatment remarkably lowered the activities of glutathione (GSH), superoxide dismutase (SOD), glutathione reductase (GSR), glutathione S-transferase (GST), glutathione peroxidase (GPx) as well as catalase (CAT) while escalated malondialdehyde (MDA) and reactive oxygen species (ROS) levels. Cisplatin administered rats exhibited significantly higher aspartate aminotransferase (AST), alanine aminotransferase (ALT) as well as alkaline phosphatase (ALP) levels. Furthermore, cisplatin administration significantly elevated the inflammatory indicators i.e., interleukin-1ß (IL-1ß), tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) as well as nuclear factor kappa-B (NF- ?B) and cyclooxygenase-2 (COX-2) activity along with histopathological impairments. Conversely, co-administration with tectochrysin effectively reversed the cisplatintriggered impairments and abnormalities in the hepatic tissue of rats. The current investigation demonstrated that tectochrysin lowered cisplatin-induced hepatotoxicity owing to its antioxidant, reactive oxygen species scavenging activities and anti-inflammatory effects.

Page(s): 366-370

DOI: 10.29261/pakvetj/2023.029

Published: Journal: Pakistan Veterinary Journal, Volume: 43, Issue: 2, Year: 2023

Keywords:

Cisplatin Tectochrysin Oxidative stress Antioxidants Inflammation Hepatotoxicity

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