To study the deteriorating effects of lithium carbonate on thyroid gland a study in albino rats | [Pakistan Journal of Medical and Health Sciences • 2022]

Author(s):

1. TAZEEN KOHARI: Islam medical and dental college Pasrur Sialkot,,Pakistan

2. ZAFFAR IQBAL MALIK: Sahara medical college Narowal, Pakistan

3. AFTAB AHMAD: Islam Medical and Dental College,Gujranwala, Pakistan

4. RANA M.ASAD KHAN: Islam medical and dental College,Sialkot, Pakistan

Abstract:

Background: The human thyroid gland is located in the front of neck. It consists of two lobes. The two lobes are joined with each other by isthmus. The mood stabilizer Lithium Caronate has deleterious effects on the thyroid gland. Aim: To observe and report the data of the harmful effect of Lithium on the weight changes of thyroid gland. METHODS: Sixteen rats were selected for this experimental study.The rodents were divided into two groups. Group A comprised of eight animals which were given laboratory diet, Group B contained eight albinos who were given Tablet Lithium Carbonate in powder form at a dose of 60 mg/day for four weeks. After completion of the study time animals were sacrificed and thyroid gland weight were recorded and compared in both groups. Results: The results in both groups were recorded and compared .It was reported that Group B animals had a highly significantly decreased thyroid weight after four weeks Lithium ingestion than Group A control group. Conclusion: The results of our study concluded that Lithium Carbonate damages thyroid glandular tissue and causes its weight to decline.

Page(s): 459-461

DOI: 10.53350/pjmhs22161459

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 16, Issue: 1, Year: 2022

Keywords:

thyroid gland , isthmus , deteriorating

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